Cheng, Guang-Shing and Sheshadri, Ajay and Turner, Jane and Williams, Kirsten M. and Hsu, Joe L. and Agoritsas, Thomas and Ali, M. Haider and Bondeelle, Louise and Bouguet, Guy and Chanez, Pascal and Cooke, Kenneth R. and Galban, Craig J. and Goldfarb, Samuel and Hallstrand, Teal S. and Johnson, Sarah and Lam, David C. L. and Michonneau, David and O'Dwyer, David N. and Paczesny, Sophie and Sharifi, Husham and Todd, Jamie L. and Wolff, Daniel and Yadav, Hemang and Yanik, Gregory A. and Bergeron, Anne (2025) Addressing Knowledge Gaps in the Early Detection of Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation An Official American Thoracic Society Research Statement. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 211 (8). pp. 1369-1390. ISSN 1073-449X, 1535-4970
Full text not available from this repository. (Request a copy)Abstract
Background: Bronchiolitis obliterans syndrome (BOS) is a late-onset noninfectious pulmonary complication of allogeneic hematopoietic cell transplant (HCT) that is often diagnosed at an advanced stage with severe lung impairment. Increasing use of HCT for the treatment of hematologic diseases worldwide translates to an increasing burden of BOS, particularly for the community pulmonologist. Early recognition of BOS, which offers the best opportunity to mitigate morbidity and mortality, is hampered by incomplete knowledge of the clinical course and disease process. The goal of this research statement is to survey our current understanding of BOS and to define the research agenda for the detection of BOS. Methods: We convened a multidisciplinary panel that included community representatives for an in-depth survey of the published literature followed by an online workshop. Results: Major knowledge gaps were identified within interrelated themes of natural history and pathogenesis, risk factors, and the clinical diagnostic approach. Conclusions: This statement reflects the detailed assessment of identified knowledge gaps with associated key research questions, as well as a proposed research road map to stimulate cross-disciplinary collaborations from preclinical to clinical investigations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; CONSENSUS DEVELOPMENT PROJECT; BONE-MARROW-TRANSPLANTATION; LUNG ALLOGRAFT DYSFUNCTION; RESPIRATORY VIRAL-INFECTIONS; MACHINE LEARNING ALGORITHMS; FOLLICULAR HELPER-CELLS; UMBILICAL-CORD BLOOD; AIR-FLOW OBSTRUCTION; MURINE CHRONIC GVHD; bronchiolitis obliterans; graft-versus-host disease; late onset noninfectious pulmonary complications; diagnosis; hematopoietic cell transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2026 12:30 |
| Last Modified: | 26 Mar 2026 12:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67985 |
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