Simon, Michaela and Melzl, Holger and Hiergeist, Andreas and Richert, Katharina and Falgenhauer, Linda and Pfeifer, Yvonne and Gerlach, Roman G. and Fuchs, Kornelius and Reischl, Udo and Gessner, Andre and Jantsch, Jonathan (2017) Colistin- and carbapenem-resistant Klebsiella oxytoca harboring bla(VIM-2) and an insertion in the mgrB gene isolated from blood culture. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 307 (2). pp. 113-115. ISSN 1438-4221, 1618-0607
Full text not available from this repository. (Request a copy)Abstract
A carbapenemase-producing colistin-resistant Klebsiella oxytoca isolate was recovered from a blood culture of a female patient without previous report of risk factors to obtain multidrug-resistant Gram-negative bacilli. A combination of biochemical and molecular methods was used to identify the resistance mechanism of this isolate. Carbapenemase production was mediated by Verona integron-encoded metallo-S-lactamase (VIM)-2. Colistin resistance was not due to plasmid- borne mcr-1 gene, but we found an integration of IS5-like sequence in the mgrB gene of K. oxytoca. This gene is known to be an important regulator of the PhoPQtwo-component system, and the disruption of this gene is most likely the cause of lipid A modification resulting in colistin resistance of our isolate. To the best of our knowledge this constitutes the first report of a carbapenemase-producing K. oxytoca with colistin resistance, a case that demonstrates the limited treatment options for infections with multidrug-resistant organisms. (C) 2017 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAPID DETECTION; ENTEROBACTERIACEAE; PNEUMONIAE; Multidrug-resistant; Klebsiella oxytoca; Colistin resistance; Metallo-beta-lactamase |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 12:57 |
| Last Modified: | 13 Feb 2019 14:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/68 |
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