Bjelic-Radisic, Vesna and Cardoso, Fatima and Weis, Joachim and Pogoda, Katarzyna and Arraras, Juan Ignacio and Greimel, Elfriede and Bottomley, Andrew and Cameron, David and Brain, Etienne and Hartup, Sue and Vieira, Rene Alosio Da Costa and Hoefnagels, Nicolette and Huang, Chi Shen and Shamieh, Omar and Pinto, Monica and Belay, Yarad Belete and Serpentini, Samantha and Bleiker, Eveline and Nookala, Manjunath and Shimomura, Akihiko and Sturm-Inwald, Elisabeth and Getu, Mikyas Amare and Bliem, Brigitte and Astrup, Guro and Morag, Ofir and Kikawa, Yuichiro and Kuljanic, Karin and Nevries, Nora and Sprangers, Mirjam and Aaronson, Neil and Sinai, Parisa and Tomaszweski, Krzysztof and Galalae, Razvan and Conroy, Thierry and Duhoux, Francois and Chie, Wei-chu and Velikova, Galina (2025) An international Phase IV field study - psychometric properties of the updated module on assessing quality of life of patients with breast cancer EORTC QLQ-BR42. BREAST, 80: 103890. ISSN 0960-9776, 1532-3080
Full text not available from this repository. (Request a copy)Abstract
Background: The EORTC QLQ-BR23, published in 1996, was one of the first disease-specific questionnaires to assess health-related quality of life (HRQoL) in patients with breast cancer (BC). In the last decades, major changes in BC treatment have occurred, requiring an update of this module. The results of the Phase 1-3 of the study were published in 2019. The aim of study was to examine the psychometric properties of the provisional EORTC-QLQ-BR45.questionnaire. Methods: Patients with a diagnosis of BC, age >= 18 years, and cognitive able to fill the questionnaire were included in the study and completed the provisional questionnaire during a visit at each participating centre. Psychometric analyses included the evaluation of the scale structure, internal consistency, test-retest reliability, convergent, discriminant, and clinical validity, and responsiveness to change. Results: Between May 2019 and September 2021, 576 patients from 22 centers (17 countries, 16 languages) were enrolled in the study. The psychometric analyses resulted in a final questionnaire containing 42 items divided into 10 scales: Breast Symptoms, Body Image, Sexual Functioning, Arm Symptoms, Systemic Chemotherapy Side Effects, Hand/Feet Symptoms/Neuropathy, Skeletal Symptoms, Endocrine Symptoms, Breast Satisfaction, Vaginal Symptoms, and 3 single items: Weight Gain, Sexual Enjoyment and Future Perspective. Conclusion: The revised EORTC QLQ-BR42 questionnaire incorporates the EORTC-QLQ-BR23 original items, combined with 19 new items that address the new therapies developed over the past 20 years. This comprehensive module is a valid instrument to assess the HRQoL of BC patients and can be used in place of the BR23 in future trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EUROPEAN-ORGANIZATION; Breast cancer; Quality of life; Questionnaire; EORTC; Psychometrics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2026 12:38 |
| Last Modified: | 25 Mar 2026 12:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/68019 |
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