Hamm, Jacob and Busana, Alzbeta and Amanzada, Ahmad and Arlt, Alexander and Asendorf, Thomas and Carswell, Samantha and Denzer, Ulrike and Elsing, Louis and Frost, Fabian and Guilabert, Lucia and Hamesch, Karim and Hollenbach, Marcus and Hegyi, Peter and Kleger, Alexander and Krivinka, Jan and Kunovsky, Lumir and Meinhardt, Christian and Phillip, Veit and Schlosser-Hupf, Sophie and Sirtl, Simon and Welsch, Lukas and von Widdern, Julian Cardinal and Neesse, Albrecht and Ammer-Herrmenau, Christoph and Beyer, Georg and Duerr, Alicia and Falt, Premysl and Gerst, Christoph and Hoffmeister, Albrecht and Kohlmann, Thomas and Knoop, Richard and Martinez-Moreno, Belen and Mayerle, Julia and Michl, Patrick and Mollnow, Tobias and Mueller, Martina and Pandanaboyana, Sanjay and Petzold, Golo and Rosendahl, Jonas and Schulte, Lucas Alexander and Seifert, Hans and Steiner-Gager, Emanuel and Sulzer, Sabrina and Urban, Ondrej and Zoundjiekpon, Vincent Dansou and Ellenrieder, Volker (2025) Effect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study. ENDOSCOPY, 57 (8). pp. 829-838. ISSN 0013-726X, 1438-8812
Full text not available from this repository. (Request a copy)Abstract
Background Lumen-apposing metal stents (LAMS) are widely used to drain walled-off necrosis (WON). LAMS occlusion is a significant clinical problem and identification of risk factors for LAMS occlusion could contribute to novel preventive strategies. A previous study suggested contradictory effects of proton pump inhibitors (PPIs) on occlusion and necrosectomy rates. Methods We conducted a Europe-wide multicenter retrospective cohort study assessing WONs drained by LAMS. The primary aims were to assess the strength of association between PPI intake and LAMS occlusion and necrosectomy rates, respectively. The secondary aim was to assess the strength of association between PPI intake and other LAMS-associated complications. Multiple mixed-effects models were used to control for possible confounding covariates. Results 893 patients with 967 LAMS from 17 centers were included. After excluding incomplete datasets and patients who took PPIs intermittently, 768 LAMS remained. The overall occlusion rate was 28.0 %. Most occlusions occurred within 10 days. Most patients received PPIs continuously (n = 577 vs. no intake n = 191). In patients who did not use PPIs continuously, lower rates of LAMS occlusion (odds ratio [OR] 0.61, P = 0.04) and necrosectomies (incidence rate ratio 0.8, P = 0.006) were observed. A post hoc analysis exhibited a dose- and compound-dependent effect of PPI intake on necrosectomy rate. No increase in other complications in the non-PPI group, such as bleeding events (OR 1.14) were observed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PANCREATIC FLUID COLLECTIONS; MANAGEMENT; THERAPY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2026 14:38 |
| Last Modified: | 24 Mar 2026 14:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/68028 |
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