Larue, Marion and Malard, Florent and Alaskar, Ahmed S. and Aljurf, Mahmoud and Arat, Mutlu and Balsat, Marie and Baron, Frederic and Basak, Grzegorz and Bazarbachi, Ali and Bonifazi, Francesca and Brissot, Eolia and Ciceri, Fabio and Corbacioglu, Selim and Dignan, Fiona and Huynh, Anne and Kenyon, Michelle and Kuball, Juergen and Lachance, Silvy and Masszi, Tamas and Nagler, Arnon and Okamoto, Shinichiro and Pagliuca, Antonio and Ruggeri, Annalisa and Ruutu, Tapani and Yakoub-Agha, Ibrahim and Ye, Yishan and Duarte, Rafael F. and Peric, Zinaida and Carreras, Enric and Mohty, Mohamad (2025) Management of liver sinusoidal obstruction syndrome/veno-occlusive disease in adults: a 2025 perspective from an international expert group. BONE MARROW TRANSPLANTATION, 60 (7). pp. 1002-1008. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Sinusoidal obstruction syndrome (SOS) formerly known as Veno-occlusive disease (VOD) is a potentially fatal complication that occurs mainly after haematopoietic cell transplantation, especially allogeneic transplantation. The liver is the principal organ affected, though other organs, such as the lungs, may also be involved to a lesser extent. The condition is characterised by obstruction of the hepatic venules, leading to sinusoidal congestion, hepatic ischaemia and, in severe cases, fulminant liver failure. Recent refined diagnostic criteria, published by the European Society for Blood and Marrow Transplantation in 2023, provide a more accurate method of detecting SOS/VOD, allowing earlier intervention and better stratification of patients according to the severity of their disease. This article focuses on liver SOS/VOD and discussing key risk factors, new diagnostic methods and therapeutic strategies, with an emphasis on the early use of defibrotide, which remains the reference treatment for severe SOS/VOD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; VENOOCCLUSIVE DISEASE; DEFIBROTIDE; DIAGNOSIS; CLASSIFICATION; ELASTOGRAPHY; CRITERIA; VOD/SOS; BLOOD; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2026 14:11 |
| Last Modified: | 24 Mar 2026 14:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/68036 |
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