Seidel, Danila and Pana, Zoi Dorothea and Ebrahimi-Fakhari, Daniel and Butzer, Sarina K. and Mehler, Katrin and Reinhold, Ilana and Simon, Arne and Dohna-Schwake, Christian and Mack, Ines and Bodmer, Nicole and Niehues, Tim and Claviez, Alexander and Laengler, Alfred and Leipold, Alfred and Prokop, Aram and Brummel, Bastian and Winkler, Beate and Gruhn, Bernd and Classen, Carl Friedrich and Friedrich, Carsten and Koenig, Christa and Flotho, Christian and Poyer, Fiona and Schilling, Freimut and Calaminus, Gabriele and Sieben, Geeke and Schwabe, Georg C. and Reinhard, Harald and Teltschik, Heiko-Manuel and Hengartner, Heinz and Stursberg, Jana and Greiner, Jeanette and Greil, Johann and Leyh, Joerg and Kuehl, Joern-Sven and Ehlert, Karoline and Bochennek, Konrad and Rohde, Marius and Demmert, Martin and Stiefel, Martina and Eyrich, Matthias and Siepermann, Meinolf and Fruehwald, Michael and Doering, Michaela and Nathrath, Michaela and Minkov, Milen and Streiter, Monika and Jones, Neil and Naumann-Bartsch, Nora and Jorch, Norbert and Beck, Olaf and Beier, Rita and Crazzolara, Roman and Kietz, Silke and Vieth, Simon and Froehling, Stefan and Lobitz, Stephan and Ghosh, Sujal and Vallee, Tanja C. and Mueller, Thilo and Wiesel, Thomas and Daebritz, Tobias and Kontny, Udo and Thiel, Uwe and Strenger, Volker and Eberl, Wolfgang R. and Cornely, Oliver A. and Groll, Andreas H. and Lehrnbecher, Thomas (2025) Approaches to Invasive Fungal Diseases in Paediatric Cancer Centres: An Analysis of Current Practices and Challenges in Germany, Austria and Switzerland. MYCOSES, 68 (6): e70074. ISSN 0933-7407, 1439-0507
Full text not available from this repository. (Request a copy)Abstract
BackgroundInvasive fungal diseases (IFD) pose significant challenges in paediatric oncology. Their management is complicated by limited paediatric-specific evidence, lack of standardised protocols and variability in resources across centres. This study assessed current practices and addressed the challenges in the prevention, diagnosis and treatment of IFDs in paediatric oncology centres across Germany, Austria and Switzerland.MethodsA questionnaire was distributed to senior paediatric oncologists in 70 paediatric oncology centres across Germany, Austria and Switzerland, gathering data on centre infrastructure, infectious disease (ID) expertise, annual cumulative IFD incidence in 2023, diagnostic tools, antifungal prophylaxis, treatment and follow-up practices for IFD. Responses were analysed descriptively.ResultsSixty-two centres responded, with a median of 56 (IQR 40-75) new oncological diagnoses per centre; 54.8% of centres managed allogeneic HCT patients. IFDs were reported in 88.7% of centres, with a median cumulative IFD incidence of 4.6% (IQR 3.0%-5.9%). No significant association was found between cumulative IFD incidence and the number of transplants, antifungal prophylaxis protocols and availability of ID consultation services. ID consultation was available in 58.1% of centres, with 24/7 support provided in 41.7% of these centres. Larger centres more frequently had paediatric ID specialists, ID consultation services and access to therapeutic drug monitoring.ConclusionsThe observed heterogeneity in mycology expertise and IFD management strategies across centres reflects the inherent complexity of IFDs and the diagnostic and therapeutic uncertainties amid limited evidence. Strengthening oncology-ID networks and implementing digital consultation platforms may promote high-quality, equitable care, particularly for those with fewer in-house resources.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CLINICAL MANAGEMENT; 2016 UPDATE; DIAGNOSIS; CHILDREN; INFECTIONS; SOCIETY; ASPERGILLOSIS; GALACTOMANNAN; GUIDELINES; ONCOLOGY; antifungal stewardship; aspergillosis; cancer; candidaemia; children; diagnosis; management; mycoses; prophylaxis; treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2026 10:56 |
| Last Modified: | 23 Mar 2026 10:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/68111 |
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