Schulz, Matthias C. and Kowald, Jan and Estenfelder, Sven and Jung, Roland and Kuhlisch, Eberhard and Eckelt, Uwe and Mai, Ronald and Hofbauer, Lorenz C. and Stroszczynski, Christian and Stadlinger, Bernd (2017) Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs. FRONTIERS IN PHYSIOLOGY, 8: 426. ISSN 1664-042X,
Full text not available from this repository. (Request a copy)Abstract
Osteoporosis is a systemic bone disease with an increasing prevalence in the elderly population. There is conflicting opinion about whether osteoporosis affects the alveolar bone of the jaws and whether it poses a risk to the osseointegration of dental implants. The aim of the present study was to evaluate the effects of systemic glucocorticoid administration on the jaw bone density of minipigs. Thirty-seven adult female minipigs were randomly divided into two groups. Quantitative computed tomography (QCT) was used to assess bone mineral density BMD of the lumbar spine as well as the mandible and maxilla, and blood was drawn. One group of minipigs initially received 1.0mg prednisolone per kg body weight daily for 2 months. The dose was tapered to 0.5mg per kg body weight per day thereafter. The animals in the other group served as controls and received placebo. QCT and blood analysis were repeated after 6 and 9 months. BMD was compared between the two groups by measuring Hounsfield units, and serum levels of several bone metabolic markers were also assessed. A decrease in BMD was observed in the jaws from baseline to 9 months. This was more pronounced in the prednisolone group. Statistically significant differences were reached for the mandible (p < 0.001) and the maxilla (p < 0.001). The administration of glucocorticoids reduced the BMD in the jaws of minipigs. The described model shows promise in the evaluation of osseointegration of dental implants in bone that is compromised by osteoporosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSTMENOPAUSAL WOMEN; SERUM OSTEOCALCIN; CORTICOSTEROID TREATMENT; GLUCOCORTICOID THERAPY; ALKALINE-PHOSPHATASE; COMPUTED-TOMOGRAPHY; IMPLANT INTEGRATION; LUMBAR VERTEBRA; FRACTURE STATUS; ANIMAL-MODELS; animal models; bone; bone mineralization; oral cavity; osteoporosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 21 Feb 2019 12:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/685 |
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