Slattery, David A. and Neumann, Inga D. and Flor, Peter J. and Zoicas, Iulia (2017) Pharmacological modulation of metabotropic glutamate receptor subtype 5 and 7 impairs extinction of social fear in a time-point-dependent manner. BEHAVIOURAL BRAIN RESEARCH, 328. pp. 57-61. ISSN 0166-4328, 1872-7549
Full text not available from this repository. (Request a copy)Abstract
Pharmacological modulation of metabotropic glutamate receptor subtype 5 (mGluR5) and 7 (mGluR7) was shown to attenuate the acquisition and to facilitate the extinction of cued and contextual, non-social, fear. Using the allosteric mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) and the allosteric mGluR7 agonist N,N'-dibenzyhydryl-ethane-1,2-diamine dihydrochloride (AMN082), we aimed to study how pharmacological blockade of mGluR5 and activation of mGluR7 influence acquisition and extinction of social fear in mice. We could show that when administered before social fear conditioning, neither MPEP nor AMN082 affected acquisition and extinction of social fear, suggesting that mGluR5 inactivation and mGluR7 activation do not alter social fear. However, when administered before social fear extinction, both MPEP and AMN082 impaired social fear extinction and extinction recall. These findings suggest that mGluR5 inactivation and mGluR7 activation are unlikely to prevent the formation of traumatic social memories. Furthermore, medication strategies aimed at augmenting exposure-based therapies for psychiatric disorders associated with social deficits via modulation of mGluR5 and mGluR7 must be pursued cautiously because of their potential to delay social fear extinction processes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITIVE ALLOSTERIC MODULATION; POSTTRAUMATIC-STRESS-DISORDER; D-CYCLOSERINE; CONTROLLED-TRIAL; FACILITATES EXTINCTION; EXPOSURE THERAPY; ANXIETY DISORDER; CONDITIONED FEAR; REDUCES FEAR; MALE-MICE; Social fear conditioning extinction; MPEP; AMN082; mGluR5; mGluR7 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor) Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 15 Feb 2019 11:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/692 |
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