Sikic, Danijel and Breyer, Johannes and Hartmann, Arndt and Burger, Maximilian and Erben, Philipp and Denzinger, Stefan and Eckstein, Markus and Stohr, Robert and Wach, Sven and Wullich, Bernd and Keck, Bastian and Wirtz, Ralph M. and Otto, Wolfgang (2017) High Androgen Receptor mRNA Expression Is Independently Associated with Prolonged Cancer-Specific and Recurrence-Free Survival in Stage T1 Bladder Cancer. TRANSLATIONAL ONCOLOGY, 10 (3). pp. 340-345. ISSN 1936-5233,
Full text not available from this repository. (Request a copy)Abstract
INTRODUCTION: High-risk non-muscle-invasive bladder cancer (NMIBC) remains challenging given the high probability of progression. Given that the androgen receptor (AR) has been discussed as a possible factor in the development and progression of bladder cancer, we investigated the predictive value of AR in stage pT1 NMIBC. MATERIALS AND METHODS: We retrospectively analyzed the clinical data and AR mRNA expression in 296 patients with stage pT1 NMIBC who underwent a transurethral resection of the bladder. The mRNA expression of the AR transcript variants 1 (AR1) and 2 (AR2) was measured by reverse transcription quantitative real-time polymerase chain reaction. AR expression was also correlated to KRT5 and KRT20 mRNA expression. RESULTS: Kaplan-Meier analysis indicated that high AR1 mRNA expression >= 35.47 is associated with statistically significant better recurrence-free survival (RFS) (P = .0007), progression-free survival (PFS) (P = .0420), and cancer-specific survival (CSS) (P = .0050). Multivariate Cox regression analysis revealed that high AR1 mRNA expression is an independent prognostic marker for RFS (P = .0029) and CSS (P = .0119). Spearman rank correlation revealed a significant positive association between mRNA expression of AR1 and KRT5 (r(s): 0.3171, P < .0001) as well as a negative association with multifocal tumors (r(s): 0.1478, P < .0109). No association was noted between AR1 expression and tumor grade, concomitant CIS, gender, tumor size, and KRT20 in patients with stage T1 NMIBC. CONCLUSIONS: AR mRNA expression can predict RFS and CSS in patients with stage T1 NMIBC. Further studies are necessary to refine the relevance of AR mRNA expression compared with immunohistochemically detectable AR expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LUMINAL SUBTYPES; CARCINOMA; MORTALITY; BASAL; IDENTIFICATION; PROGRESSION; GUIDELINES; DIAGNOSIS; THERAPY; GRADE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 19 Feb 2019 10:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/734 |
Actions (login required)
 |
View Item |
