Brandl, Caroline (2017) Cell-based therapies at the ocular fundus - past, present, future. MEDIZINISCHE GENETIK, 29 (2). pp. 208-216. ISSN 1863-5490,
Full text not available from this repository. (Request a copy)Abstract
The endpoint of most retinal degenerative disorders is a loss of cells in the retinal pigment epithelium and/or the neurosensory retina, leading to irreversible visual impairment. Therefore, therapeutic strategies in the late disease stages also need to address the replacement of lost cells or tissues. In recent years, rapid advances have been made in the field of stem cell-based cellular transplantation therapies with regard to bridging the gap between basic science and clinical application. In particular, induced pluripotent stem cells promise to significantly advance the field of personalized medicine, once major uncertainties and obstacles have been overcome. This review highlights retinal degenerative disorders in which cellular transplantation therapies provide possible treatment options, and mentiones currently available therapeutic strategies. Moreover, the potential areas of use of induced pluripotent stem cells, together with their advantages and disadvantages, are discussed. The main focus is on the stem cell-based replacement of retinal pigment epithelial cells, as the latter technique has made the most significant progress toward clinical application in comparison with other neurosensory retinal cell types. Finally, an overview is provided of clinical trials that are already established for the treatment of retinal degeneration using stem cell-based cellular transplantation therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLURIPOTENT STEM-CELLS; RETINAL-PIGMENT EPITHELIUM; AGE-RELATED MACULOPATHY; MACULAR DEGENERATION; OPHTHALMOLOGY TREATMENT; CLINICAL-TRIAL; DYSTROPHIES; RPE; SYSTEM; SCOTS; Retinal dystrophy; Age-related macular degeneration; Induced pluripotent stem cells; Retinal pigment epithelium; Haplobank |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Lehrstuhl für Humangenetik Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 18 Feb 2019 13:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/737 |
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