Wuerdinger, Michael and Modrow, Susanne and Plentz, Annelie (2017) Impact of Parvovirus B19 Viremia in Liver Transplanted Children on Anemia: A Retrospective Study. VIRUSES-BASEL, 9 (6): 149. ISSN 1999-4915,
Full text not available from this repository. (Request a copy)Abstract
Acute parvovirus B19 (B19V) infection in immunocompromised patients may lead to severe anemia. However, in adult transplant recipients, B19V reactivations without anemia and low-level viremia are common. The impact of B19V in pediatric transplant patients, with high risk of primary infection, is investigated here. In a six-month period, 159 blood samples of 54 pediatric liver transplant recipients were tested for B19V DNA by quantitative real-time PCR. Viremia was correlated with anemia and immunosuppression and compared with rates in adult transplant recipients. B19V DNA was detected in 5/54 patients. Primary B19V infections were observed in four patients prior to and in one patient after transplantation. Rates of viremia were significantly higher in pediatric recipients than in adults. Prolonged virus shedding after primary infection prior to transplantation accounts for most viremic cases. Anemia was significantly more frequent in samples from viremic patients, but remained mild. In 15% of anemic samples, B19V DNA was detected. Therefore, in anemic pediatric transplant recipients, diagnostics for B19V seem reasonable.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RED-CELL APLASIA; BONE-MARROW-TRANSPLANTATION; KIDNEY-TRANSPLANTATION; ACUTE INFECTION; RISK-FACTORS; SOLID-ORGAN; RECIPIENTS; DNAEMIA; BLOOD; PCR; parvovirus B19; children; pediatric; transplantation; anemia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 28 Feb 2019 10:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/741 |
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