Weyerer, Veronika and Schneckenpointner, Roland and Filbeck, Thomas and Burger, Maximilian and Hofstaedter, Ferdinand and Wild, Peter J. and Fine, Samson W. and Humphrey, Peter A. and Dehner, Louis P. and Amin, Mahul B. and Rueschoff, Josef and Boltze, Carsten and Tannapfel, Andrea and Zwarthoff, Ellen and Lopez-Beltran, Antonio and Montironi, Rodolfo and Langner, Cord and Stoehr, Robert and Hartmann, Arndt and Giedl, Johannes (2017) Immunohistochemical and molecular characterizations in urothelial carcinoma of bladder in patients less than 45 years. JOURNAL OF CANCER, 8 (3). pp. 323-331. ISSN 1837-9664,
Full text not available from this repository. (Request a copy)Abstract
Bladder tumours in early-onset patients are rare and seem to exhibit unique clinicopathological features. Only few studies have investigated somatic alterations in this specific age of onset group and evidence is accumulating of a distinct molecular behaviour of early-onset bladder tumours. We collected the largest cohort of early-onset tumours of patients 45 years old or younger and aimed to test genomic alterations typically found in bladder cancer. Tumours of 118 early-onset patients were compared with a consecutive group of 113 cases. Immunohistochemistry of TP53, CK20 and Ki-67 was carried out. Molecular analysis was conducted to test for loss of heterozygosity of chromosome 9 and 17, as well as TP53 and FGFR3 mutations. Fisher's exact and chi-squared test were appropriately used. No differences in grade/stage characteristics were observed. Overexpressed TP53 was differentially distributed between the two groups. TP53 nuclear accumulation was significantly more frequent in early-onset papillomas, PUNLMPs and pTa low-grade tumours compared to the consecutive cohort (P=0.005). Moreover, chromosome 9 deletions (29.5% vs. 44.6%) and FGFR3 mutations (34.5% vs. 63.7%) were less often detected in early-onset patients (p=0.05 and p < 0.0001). By comparing the largest cohort of early-onset bladder cancer patients with an unselected group, we demonstrated that the typical molecular features are not independent of age at diagnosis. Our study supports the hypothesis of a distinct biological behaviour in early-onset tumours.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL-CARCINOMA; YOUNG-ADULTS; MICROSATELLITE INSTABILITY; COLORECTAL-CANCER; GENE-MUTATIONS; TUMORS; CHROMOSOME-9; EXPRESSION; FGFR3; AGE; Early-onset; Bladder cancer; FGFR3; TP53 positivity; Mutation analysis. |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 12:57 |
| Last Modified: | 22 Feb 2019 09:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/75 |
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