Cieplik, Fabian and Buchalla, Wolfgang and Hellwig, Elmar and Al-Ahmad, Ali and Hiller, Karl-Anton and Maisch, Tim and Karygianni, Lamprini (2017) Antimicrobial photodynamic therapy as an adjunct for treatment of deep carious lesions-A systematic review. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 18. pp. 54-62. ISSN 1572-1000, 1873-1597
Full text not available from this repository. (Request a copy)Abstract
For deep carious lesions, a more conservative treatment modality ("selective caries removal") has been proposed, where only the heavily contaminated dentine is removed. In this regard, effective adjuncts for cavity disinfection such as the antimicrobial photodynamic therapy (aPDT) can be valuable clinically prior to definitive restoration. Therefore, the aim of this study was to systematically assess clinical studies on the effectiveness of aPDT as a supplementary tool in the treatment of deep caries lesions. Searches were performed in four databases (PubMed, EMBASE, ISI Web of Science, ClinicalTrials.gov) from 1st January, 2011 until 21st June, 2016 for search terms relevant to the observed parameters, pathological condition, intervention and anatomic entity. The pooled information was evaluated according to PRISMA guidelines. At first, 1651 articles were recovered, of which 1249 full-text articles were evaluated, 270 articles thereof were reviewed for eligibility and finally 6 articles met all inclusion criteria. The aPDT protocols involved Methylene Blue, Toluidine Blue and aluminium-chloride-phthalocyanine as photosensitizers and diode lasers, light-emitting diodes and halogen light-sources. The data from five reports, utilizing both culture-dependent and -independent methods, disclosed significant reduction of cariogenic bacterial load after mechanical caries removal with adjunct aPDT. As these studies exhibit some methodological limitations, e.g. lack of positive controls, this systematic review can support the application of aPDT to a limited extent only in terms of reducing the microbial load in deep carious lesions before restorative treatment. (C) 2017 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORAL KEY PATHOGENS; IN-VITRO; SINGLET OXYGEN; CARIES LESIONS; DENTINAL TUBULES; INACTIVATION; CHEMOTHERAPY; BACTERIA; PHOTOSENSITIZERS; BIOFILMS; Deep carious lesions; Caries treatment; Antimicrobial; Photodynamic; aPDT |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie > Dr. rer. nat. Karl-Anton Hiller |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 01 Oct 2020 06:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/757 |
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