Moschall, Rebecca and Gaik, Monika and Medenbach, Jan (2017) Promiscuity in post-transcriptional control of gene expression: Drosophila sex-lethal and its regulatory partnerships. FEBS LETTERS, 591 (11). pp. 1471-1488. ISSN 1873-3468
Full text not available from this repository. (Request a copy)Abstract
The Drosophila RNA-binding protein Sex-lethal (Sxl) is a potent post-transcriptional regulator of gene expression that controls female development. It regulates the expression of key factors involved in sex-specific differences in morphology, behavior, and dosage compensation. Functional Sxl protein is only expressed in female flies, where it binds to U-rich RNA motifs present in its target mRNAs to regulate their fate. Sxl is a very versatile regulator that, by shuttling between the nucleus and the cytoplasm, can regulate almost all aspects of post-transcriptional gene expression including RNA processing, nuclear export, and translation. For these functions, Sxl employs multiple interactions to either antagonize RNA-processing factors or to recruit various coregulators, thus allowing it to establish a female-specific gene expression pattern. Here, we summarize the current knowledge about Sxl function and review recent mechanistic and structural studies that further our understanding of how such a seemingly 'simple' RNA-binding protein can exert this plethora of different functions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRE-MESSENGER-RNA; GERMLINE STEM-CELL; BAG-OF-MARBLES; DOSAGE COMPENSATION GENE; TRANSLATIONAL CONTROL; SPLICE-SITE; BINDING PROTEIN; HU PROTEINS; MALE EXON; POLYPYRIMIDINE-TRACT; alternative splicing; post-transcriptional regulation of gene expression; RNA-binding protein; sex determination; sex-lethal; translational control |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 22 Sep 2020 07:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/764 |
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