Prokein, Benjamin and Holtmann, Henrik and Hautmann, Matthias G. and Rosler, Hans-Peter and Graeber, Stefan and Dzierma, Yvonne and Ruebe, Christian and Fleckenstein, Jochen and Niewald, Marcus (2017) Radiotherapy of painful heel spur with two fractionation regimens. STRAHLENTHERAPIE UND ONKOLOGIE, 193 (6). pp. 483-490. ISSN 0179-7158, 1439-099X
Full text not available from this repository. (Request a copy)Abstract
Background In this randomized multicenter trial, we compared the effect of a lower single dose of 0.5 Gy vs. a standard single dose of 1 Gy concerning pain relief and quality of life, while maintaining a uniform total dose of 6 Gy. On the basis of laboratory observations, the lower single dose would be expected to be more effective. Patients and methods A total of 127 patients suffering from painful heel spur were randomized: Patients in the standard group were treated with single fractions of 6 x 1 Gy twice a week, while the experimental group was treated with single fractions of 12 x 0.5 Gy three times a week. Patients who did not show satisfactory pain relief after 12 weeks were offered re-irradiation with the standard dose. The study's primary endpoints were pain relief and quality of life. Therapy results were evaluated and compared based on follow-up examinations after 12 and 48 weeks. Results The data of 117 patients could be evaluated. There was no significant difference between the groups concerning the results of a visual analogue scale (VAS), Calcaneodynia Score (CS), and the somatic scale of the 12-Item Short-Form Health Survey(SF-12). Patients undergoing re-irradiation showed a significant benefit concerning pain relief. Their total outcome was comparable to patients showing a good response from the beginning. No relevant acute or chronic side effects were recorded. Conclusion Both patient groups showed good results concerning pain relief. A fractionation schedule of 12 x 0.5 Gy was not superior to the current standard dose of 6 x 1 Gy. Further trials are necessary to explore the best fractionation schedule.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-DOSE RADIATION; EA.HY.926 ENDOTHELIAL-CELLS; MULTICENTER FOLLOW-UP; NF-KAPPA-B; X-IRRADIATION; TRANSCRIPTIONAL ACTIVITY; BIPHASIC INDUCTION; THERAPY; TRIAL; ADHESION; Radiotherapy; Calcaneal spur; Pain; Quality of life; Analgesia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 28 Feb 2019 10:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/809 |
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