Freisling, Heinz and Arnold, Melina and Soerjomataram, Isabelle and O'Doherty, Mark George and Ordonez-Mena, Jose Manuel and Bamia, Christina and Kampman, Ellen and Leitzmann, Michael and Romieu, Isabelle and Kee, Frank and Tsilidis, Konstantinos and Tjonneland, Anne and Trichopoulou, Antonia and Boffetta, Paolo and Benetou, Vassiliki and Bueno-de-Mesquita, H. B. (as) and Maria Huerta, Jose and Brenner, Hermann and Wilsgaard, Tom and Jenab, Mazda (2017) Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe. BRITISH JOURNAL OF CANCER, 116 (11). pp. 1486-1497. ISSN 0007-0920, 1532-1827
Full text not available from this repository. (Request a copy)Abstract
Background: We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obesity, with total obesity-related and site-specific (colorectal and postmenopausal breast) cancer incidence. Methods: This is a meta-analysis of seven prospective cohort studies participating in the CHANCES consortium including 18 668 men and 24 751 women with a mean age of 62 and 63 years, respectively. Harmonised individual participant data from all seven cohorts were analysed separately and alternatively for each anthropometric indicator using multivariable Cox proportional hazards models. Results: After a median follow-up period of 12 years, 1656 first-incident obesity-related cancers (defined as postmenopausal female breast, colorectum, lower oesophagus, cardia stomach, liver, gallbladder, pancreas, endometrium, ovary, and kidney) had occurred in men and women. In the meta-analysis of all studies, associations between indicators of adiposity, per s.d. increment, and risk for all obesity-related cancers combined yielded the following summary hazard ratios: 1.11 (95% CI 1.02-1.21) for BMI, 1.13 (95% CI 1.04-1.23) for WC, 1.09 (95% CI 0.98-1.21) for HC, and 1.15 (95% CI 1.00-1.32) for WHR. Increases in risk for colorectal cancer were 16%, 21%, 15%, and 20%, respectively per s. d. of BMI, WC, HC, and WHR. Effect modification by hormone therapy (HT) use was observed for postmenopausal breast cancer (P-interaction < 0.001), where never HT users showed an similar to 20% increased risk per s. d. of BMI, WC, and HC compared to ever users. Conclusions: BMI, WC, HC, and WHR show comparable positive associations with obesity-related cancers combined and with colorectal cancer in older adults. For postmenopausal breast cancer we report evidence for effect modification by HT use.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOSE-RESPONSE METAANALYSIS; NIH-AARP DIET; MASS INDEX; GASTRIC ADENOCARCINOMA; ANTHROPOMETRIC FACTORS; WAIST CIRCUMFERENCE; COLORECTAL-CANCER; PANCREATIC-CANCER; ABDOMINAL OBESITY; UNITED-STATES; CHANCES consortium; ageing; cohort; obesity; body fat distribution; cancer; prevention |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 25 Feb 2019 13:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/867 |
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