Peled, Jonathan U. and Devlin, Sean M. and Staffas, Anna and Lumish, Melissa and Khanin, Raya and Littmann, Eric R. and Ling, Lilan and Kosuri, Satyajit and Maloy, Molly and Slingerland, John B. and Ahr, Katya F. and Rodriguez, Kori A. Porosnicu and Shono, Yusuke and Slingerland, Ann E. and Docampo, Melissa D. and Sung, Anthony D. and Weber, Daniela and Alousi, Amin M. and Gyurkocza, Boglarka and Ponce, Doris M. and Barker, Juliet N. and Perales, Miguel-Angel and Giralt, Sergio A. and Taur, Ying and Pamer, Eric G. and Jenq, Robert R. and van den Brink, Marcel R. M. (2017) Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation. JOURNAL OF CLINICAL ONCOLOGY, 35 (15). 1650-+. ISSN 0732-183X, 1527-7755
Full text not available from this repository. (Request a copy)Abstract
PurposeThe major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora are associated with GVHD, bacteremia, and reduced overall survival after allo-HCT. Because intestinal bacteria are potent modulators of systemic immune responses, including antitumor effects, we hypothesized that components of the intestinal flora could be associated with relapse after allo-HCT.MethodsThe intestinal microbiota of 541 patients admitted for allo-HCT was profiled by means of 16S ribosomal sequencing of prospectively collected stool samples. We examined the relationship between abundance of microbiota species or groups of related species and relapse/progression of disease during 2 years of follow-up time after allo-HCT by using cause-specific proportional hazards in a retrospective discovery-validation cohort study.ResultsHigher abundance of a bacterial group composed mostly of Eubacterium limosum in the validation set was associated with a decreased risk of relapse/progression of disease (hazard ratio [HR], 0.82 per 10-fold increase in abundance; 95% CI, 0.71 to 0.95; P = .009). When the patients were categorized according to presence or absence of this bacterial group, presence also was associated with less relapse/progression of disease (HR, 0.52; 95% CI, 0.31 to 0.87; P = .01). The 2-year cumulative incidences of relapse/progression among patients with and without this group of bacteria were 19.8% and 33.8%, respectively. These associations remained significant in multivariable models and were strongest among recipients of T-cell-replete allografts.ConclusionWe found associations between the abundance of a group of bacteria in the intestinal flora and relapse/progression of disease after allo-HCT. These might serve as potential biomarkers or therapeutic targets to prevent relapse and improve survival after allo-HCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; UNRELATED DONORS; GUT MICROBIOTA; CORD-BLOOD; LEUKEMIA; CYCLOPHOSPHAMIDE; INFLAMMATION; DIVERSITY; MORTALITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 28 Feb 2019 10:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/870 |
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