Wodarz, Norbert and Krampe-Scheidler, Anne and Christ, Michael and Fleischmann, Heribert and Looser, Winfried and Schoett, Katharina and Vilsmeier, Frank and Bothe, Lydia and Schaefer, Corinna and Gouzoulis-Mayfrank, Euphrosyne (2017) Evidence-Based Guidelines for the Pharmacological Management of Acute Methamphetamine-Related Disorders and Toxicity. PHARMACOPSYCHIATRY, 50 (3). pp. 87-95. ISSN 0176-3679, 1439-0795
Full text not available from this repository.Abstract
Consumption of methamphetamine ("crystal") has spread dramatically over several European countries. The management of methamphetamine-induced acute disorders has become a growing challenge to the health system. Pharmacological treatment strategies for methamphetamine-induced intoxication syndromes, acute withdrawal symptoms, and methamphetamine-induced psychosis are particularly important. ;The development of interdisciplinary and evidence-and consensus-based (S3) German Guidelines was based on a systematic literature and guideline search on therapeutic interventions in methamphetamine-related disorders (April, June 2015). Consideration was given to 9 guidelines and 103 publications. Recommendations on pharmacological treatment strategies were drawn up using the nominal group technique. Overall, only limited evidence is available. Benzodiazepines are first-line medication for methamphetamine-induced intoxication syndromes, particularly when they present with acute agitation and aggressive behavior. There is no evidence-based medication for the treatment of methamphetamine-related withdrawal symptoms and cravings. When treating methamphetamine-induced psychosis, second-generation antipsychotics should be favored, given their more favorable side-effect profile. The indication for continuation of antipsychotic medication must be reviewed regularly. In most cases, the antipsychotic should be tapered off within 6 months.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; DEPENDENT VOLUNTEERS; INDUCED PSYCHOSIS; N-ACETYLCYSTEINE; SHORT-TERM; WITHDRAWAL; MODAFINIL; ARIPIPRAZOLE; (Crystal) methamphetamine; intoxication; withdrawal; methamphet-amine-induced psychosis; treatment guidelines |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 01 Oct 2020 06:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/902 |
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