Cabrele, Chiara and Martinek, Tamas A. and Reiser, Oliver and Berlicki, Lukasz (2014) Peptides Containing beta-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry. JOURNAL OF MEDICINAL CHEMISTRY, 57 (23). pp. 9718-9739. ISSN 0022-2623, 1520-4804
Full text not available from this repository. (Request a copy)Abstract
The construction of bioactive peptides using beta-amino acid-containing sequence patterns is a very promising strategy to obtain analogues that exhibit properties of high interest for medicinal chemistry applications. beta-Amino acids have been shown to modulate the conformation, dynamics, and proteolytic susceptibility of native peptides. They can be either combined with alpha-amino acids by following specific patterns, which results in backbone architectures with well-defined orientations of the side chain functional groups, or assembled in de novo-designed bioactive beta- or alpha,beta-peptidic sequences. Such peptides display various biological functions, including antimicrobial activity, inhibition of proteinprotein interactions, agonism/antagonism of GPCR ligands, and anti-angiogenic activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DE-NOVO DESIGN; PROTEIN-PROTEIN INTERACTIONS; ALPHA-HELIX MIMICRY; HUMAN SOMATOSTATIN RECEPTOR; PARALLEL SHEET STRUCTURE; GLUCAGON-LIKE PEPTIDE-1; GENE-RELATED PEPTIDE; O HYDROGEN-BONDS; NEUROPEPTIDE-Y; HETEROGENEOUS BACKBONES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Aug 2019 13:31 |
| Last Modified: | 05 Aug 2019 13:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9053 |
Actions (login required)
 |
View Item |
