Koehler, Julia and Wallmeyer, Leonie and Hedtrich, Sarah and Goepferich, Achim M. and Brandl, Ferdinand P. (2017) pH-Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds. MACROMOLECULAR BIOSCIENCE, 17 (5): 1600369. ISSN 1616-5187, 1616-5195
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The development of chronic wounds has been frequently associated with alkaline pH values. The application of pH-modulating wound dressings can, therefore, be a promising treatment option to promote normal wound healing. This study reports on the development and characterization of acidic hydrogel dressings based on interpenetrating poly(ethylene glycol) diacrylate/acrylic acid/alginate networks. The incorporation of ionizable carboxylic acid groups results in high liquid uptake up to 500%. The combination of two separate polymer networks significantly improves the tensile and compressive stability. In a 2D cell migration assay, the application of hydrogels (0% to 1.5% acrylic acid) results in complete "wound" closure; hydrogels with 0.25% acrylic acid significantly increase the cell migration velocity to 19.8 +/- 1.9 mu m h(-1). The most promising formulation (hydrogels with 0.25% acrylic acid) is tested on 3D human skin constructs, increasing keratinocyte ingrowth into the wound by 164%.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLYMER NETWORK HYDROGELS; IN-VITRO; MECHANICAL-PROPERTIES; DRUG-DELIVERY; ANIMAL-MODEL; SKIN; ALGINATE; STRENGTH; REPAIR; ARCHITECTURE; chronic wound; hydrogels; interpenetrating networks (IPN); reconstructed human skin; wound dressing |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 11 Feb 2019 13:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/913 |
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