Ackermann, M. and Kubitza, M. and Hauska, G. and Pina, A. L. (2014) The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria. CELL AND TISSUE RESEARCH, 358 (3). pp. 779-792. ISSN 0302-766X, 1432-0878
Full text not available from this repository. (Request a copy)Abstract
Hydrogen sulfide (H2S) is the first inorganic compound identified as both a substrate for mitochondrial oxidative phosphorylation and a transmitter in mammalian cells. H2S seems to mediate effects that are correlated with those of nitric oxide (NO) by a reciprocal regulation. Moreover, H2S is consumed by mitochondrial oxidation mediated by sulfide-quinone reductase-like protein (SQRDL)-the vertebrate homolog of sulfide-quinone oxidoreductase (SQR). There is evidence that SQR plays an essential role in regulating H2S levels in fission yeast. To start understanding the role of SQRDL in the mammalian metabolism of H2S, we examine rat tissues. Our results show that SQRDL protein is present in all tissues tested, albeit restricted to specific mitochondrial populations at the cellular level. We demonstrate a developmental regulation of Sqrdl transcription in the kidney, where SQRDL protein is detectable in glomerular podocytes and in tubular cells of the renal medulla. We also show that Sqrdl transcription in T cells is responsive to external H2S. Taken together, our results suggest that Sqrdl transcription is adaptively regulated, probably to meet the need of H2S oxidation. Thus far, SQRDL has only been studied in a limited set of tissues. The present report demonstrates the presence and specific localization of SQRDL in various mammalian tissues.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN DENDRITIC CELLS; HYDROGEN-SULFIDE; GENE-EXPRESSION; RHODOBACTER-CAPSULATUS; HELICOBACTER-PYLORI; OXIDOREDUCTASE SQR; OXIDATIVE STRESS; SPERM CHROMATIN; NATURAL-WATERS; NITRIC-OXIDE; SQRDL; Hydrogen sulfide; Kidney; Mitochondria; Podocytes; Tubular cells |
| Subjects: | 500 Science > 580 Botanical sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Aug 2019 09:45 |
| Last Modified: | 07 Aug 2019 09:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9157 |
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