Gerber, B. and Ortmann, O. (2014) Prevention of Early Menopause Study (POEMS): is it possible to preserve ovarian function by gonadotropin releasing hormone analogs (GnRHa)? ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 290 (6). pp. 1051-1053. ISSN 0932-0067, 1432-0711
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The effect of GnRHa in the preservation of ovarian function during a modern chemotherapy is still under discussion. In this News and Views article, we discuss the benefits and weaknesses of the recently presented POEMS. The POEM study demonstrated an increased resumption of ovarian function and pregnancy rate after using GnRHa. GnRHa in HR-negative patients led to a significant increase in disease free and overall survival, with those effects being inexplicable. Weaknesses of the trial were prematurely close due to lack of recruitment, a drop-out rate of 38 % during follow-up and definition of hormone receptor negativity by < 10 % positive stained cells. Even after POEMS, there is no additional clarity regarding preservation of ovarian function during chemotherapy by GnRHa.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BREAST-CANCER; RANDOMIZED-TRIAL; CHEMOTHERAPY; TRIPTORELIN; SUPPRESSION; AGONIST; Breast cancer; GnRHa; Chemotherapy; Ovarian failure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jun 2020 08:11 |
| Last Modified: | 26 Jun 2020 08:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9166 |
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