Rengstl, Doris and Kraus, Birgit and Van Vorst, Matthew and Elliott, Gloria D. and Kunz, Werner (2014) Effect of choline carboxylate ionic liquids on biological membranes. COLLOIDS AND SURFACES B-BIOINTERFACES, 123. pp. 575-581. ISSN 0927-7765, 1873-4367
Full text not available from this repository. (Request a copy)Abstract
Choline carboxylates, ChC(m), with m = 2-10 and choline oleate are known as biocompatible substances, yet their influence on biological membranes is not well-known, and the effect on human skin has not previously been investigated. The short chain choline carboxylates ChC(m) with m = 2, 4, 6 act as hydrotropes, solubilizing hydrophobic compounds in aqueous solution, while the longer chain choline carboxylates ChC(m) with m = 8, 10 and oleate are able to form micelles. In the present study, the cytotoxicity of choline carboxylates was tested using HeLa and SK-MEL-28 cells. The influence of these substances on liposomes prepared from dipalmitoylphosphatidylcholine (DPPC) was also evaluated to provide insights on membrane interactions. It was observed that the choline carboxylates with a chain length of m>8 distinctly influence the bilayer, while the shorter ones had minimal interaction with the liposomes. (C) 2014 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORNEAL EPITHELIAL-CELLS; ANIONIC SURFACTANTS; CHAIN-LENGTH; IN-VITRO; PHYSICAL-PROPERTIES; HOFMEISTER SERIES; AQUATIC TOXICITY; PRIMARY CULTURES; HELA-CELLS; CYTOTOXICITY; Choline ionic liquids; Biological membrane; Cytotoxicity |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Aug 2019 08:11 |
| Last Modified: | 08 Aug 2019 08:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9238 |
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