Steinfeldt, Thorsten and Wiesmann, Thomas and Nimphius, Wilhelm and Cornelius, Valer and Eismann, Daniel and Kratz, Thomas and Hadzic, Admir and Wulf, Hinnerk and Werner, Tilmann (2014) Perineural Hematoma May Result in Nerve Inflammation and Myelin Damage. REGIONAL ANESTHESIA AND PAIN MEDICINE, 39 (6). pp. 513-519. ISSN 1098-7339, 1532-8651
Full text not available from this repository. (Request a copy)Abstract
Background and Objectives: Perineural hematoma may occur during performance of peripheral nerve blocks. The aim of this study was to test the hypothesis that an iatrogenic hematoma in the immediate vicinity of a peripheral nerve may cause histologic evidence of nerve injury. Methods: Fifty milliliters of autologous blood was injected adjacent to the right sciatic nerve in 20 anesthetized female pigs. In order to discern between blood-related volume and immune effects, 50 mL of albumin was injected at the same location in an additional 22 pigs. Either blood or albumin was injected in random order. The left sciatic nerve served as a negative control in all animals, that is, either no needle placement or needle placement without injection. After 48 hours, the nerves were resected. The grade of nerve injury was scored from 0 (no injury) to 3 (severe injury) by histologic analysis of myelin tissue and inflammatory cells. Results: Eighty-two nerve specimens were examined. Injury scores were significantly (P < 0.01) higher in the blood injection (n = 20; median [interquartile range] 2 [2-2]) and albumin injection (n = 22, 1 [1-2]) conditions compared with the no needle placement (n = 22, 0 [0-1]) and "dry needle placement" (n = 20, 1 [0-1]) conditions. Widespread inflammatory changes were seen in the blood injection group, in which 15% of nerve specimens showed damage to myelin. Conclusions: Our data suggest that hematoma adjacent to nerve tissue may result in structural nerve injury and inflammatory changes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTRACEREBRAL HEMORRHAGE; SCIATIC-NERVE; PORCINE MODEL; NEUROPATHY; MACROPHAGES; COMPLICATIONS; RESIDENT; GUIDANCE; CONTACT; THERAPY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Aug 2019 14:24 |
| Last Modified: | 08 Aug 2019 14:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9260 |
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