Max, Daniela and Kuehnoel, Caspar D. and Burdach, Stefan and Niu, Liguo and Staege, Martin S. and Foell, Juergen L. (2014) Indoleamine-2,3-dioxygenase in an Immunotherapy Model for Ewing Sarcoma. ANTICANCER RESEARCH, 34 (11). pp. 6431-6441. ISSN 0250-7005, 1791-7530
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Background/Aim: Interleukin-2 (IL2) transgenic Ewing sarcoma cells reduce tumor growth in vivo and in vitro. In the present study we analyzed the expression of immune suppressive indoleamine-2,3-dioxygenase (IDO) in this model. Materials and Methods: Expression of IDO was analyzed by polymerase chain reaction. The impact of the cluster of differentiation 137 (CD137)/CD137 ligand (CD137L) co-stimulatory system on expression of IDO and different cytokines was analyzed both in vivo and in vitro. Results: Tumors that developed in vivo in the presence of IL2 transgenic tumor cells expressed IDO. The presence of CD1371, transgenic tumor cells led to down-regulation of IDO. Further in-vitro analysis of this phenomenon indicated that 1DO was expressed in tumor cells as a consequence of interferongamma produced by lymphocytes in response to IL2. Depending on the concentration of 1L2, stimulation of CD137 increased or reduced cytokine production in lymphocytes. Conclusion: Our data indicate that the CD137/CD1371, pathway can modulate the immune response against Ewing sarcoma cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T-CELL RESPONSES; INDOLEAMINE 2,3-DIOXYGENASE; IN-VIVO; TRYPTOPHAN DEGRADATION; INTERFERON-GAMMA; HODGKINS-DISEASE; MONOCLONAL-ANTIBODIES; MONOCYTE ACTIVATION; CD137 ILA/4-1BB; LEUKEMIC-CELLS; Interieukin-2; immune escape; indoleamine-2,3-dioxygenase; CD 137; Ewing sarcoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Aug 2019 14:43 |
| Last Modified: | 08 Aug 2019 14:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9263 |
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