Dornia, Christian and Philipp, Alois and Bauer, Stefan and Lubnow, Matthias and Mueller, Thomas and Lehle, Karla and Schmid, Christof and Mueller-Wille, Rene MueMmid and Wigermann, Philipp and Stroszczynski, Christian and Schreyer, Andreas G. (2014) Analysis of Thrombotic Deposits in Extracorporeal Membrane Oxygenators by Multidetector Computed Tomography. ASAIO JOURNAL, 60 (6). pp. 652-656. ISSN 1058-2916, 1538-943X
Full text not available from this repository. (Request a copy)Abstract
Oxygenator thrombosis is a serious complication in extracorporeal membrane oxygenation (ECMO) and may necessitate a system exchange. Coagulation and fibrinolysis parameters, flow dynamics, and gas transfer performance are currently used to evaluate the degree of oxygenator thrombosis, but there is no technical approach for direct visualization and quantification of thrombotic deposits within the membrane oxygenator (MO). We used multidetector computed tomography (MDCT) with three-dimensional postprocessing to assess the incidence of oxygenator thrombosis, to quantify thrombus extent, and to localize clot distribution. Twenty heparin-coated MOs after successful weaning were analyzed. Mean ECMO support time was 7 +/- 4 days, mean activated partial thromboplastin time (aPTT) during ECMO was 59 +/- 20 seconds. Thrombotic deposits were detected in all MOs. The mean clot volume was 51.7 +/- 22.3 cm(3). All thrombotic deposits were located in the venous, i.e., inlet part of the device, without apparent evidence of embolization in patients. There was no correlation between clot volume and ECMO support time or aPTT. Clot formation within the MO is a common finding in ECMO despite adequate systemic anticoagulation. The clinical significance of thrombus formation and its influence on gas exchange capacity and hemostatic complications have to be addressed in further studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUPPORT; FAILURE; ADULTS; FLOW; extracorporeal membrane oxygenation; oxygenator thrombosis; multidetector computed tomography |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Aug 2019 09:19 |
| Last Modified: | 08 Aug 2019 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9264 |
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