Kredel, Markus and Lubnow, Matthias and Westermaier, Thomas and Mueller, Thomas and Philipp, Alois and Lotz, Christopher and Kilgenstein, Christian and Kuestermann, Julian and Roewer, Norbert and Muellenbach, Ralf M. (2014) Cerebral Tissue Oxygenation During the Initiation of Venovenous ECMO. ASAIO JOURNAL, 60 (6). pp. 694-700. ISSN 1058-2916, 1538-943X
Full text not available from this repository. (Request a copy)Abstract
In an acute respiratory distress syndrome, venovenous extracorporeal membrane oxygenation (vvECMO) can rapidly normalize arterial hypoxemia and carbon dioxide tension (PaCO2). Considering the positive relationship between PaCO2 and cerebral blood flow, the aim of the current study was to evaluate cerebral regional tissue oxygen saturation (rSO(2)) during the implementation of vvECMO. Fifteen acute respiratory distress syndrome patients with recordings of cerebral rSO(2) by near-infrared spectroscopy before vvECMO implementation until the optimization of the ECMO/ventilator settings were retrospectively studied. Results: median (interquartile range). The cerebral rSO(2) increased significantly (p < 0.05) from 69(61-74) to 75(60-80)% after ECMO was started, concomitant to the arterial oxygenation. Until the end of the observation period after 83(44-132) minutes, cerebral rSO(2) decreased significantly to 61(52-71)%. PaCO2 decreased from 70(61-87) to 43(38-54) mm Hg and the pH increased from 7.23(7.14-7.29) to 7.39(7.34-7.43). The baseline arterial oxygen saturation and tension as well as the actual bicarbonate concentration were negatively correlated with the absolute change in cerebral rSO(2) (Delta rSO(2)). In the 11 nonhypoxemic patients (arterial oxygen saturation >= 90%) Delta PaCO2 was significantly correlated with Delta rSO(2). Patients receiving vvECMO treatment are at risk for a decrease in cerebral rSO(2). This decrease is more distinct in patients with normal baseline arterial oxygenation and high actual bicarbonate.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTRACORPOREAL MEMBRANE-OXYGENATION; NEAR-INFRARED SPECTROSCOPY; RESPIRATORY-DISTRESS-SYNDROME; HYPERCAPNIC ACIDOSIS; CARBON-DIOXIDE; LIFE-SUPPORT; LUNG INJURY; BLOOD-FLOW; VENTILATION; ADULTS; acute respiratory distress syndrome; acute lung injury; extracorporeal membrane oxygenation; near-infrared spectroscopy; brain injury |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Aug 2019 11:28 |
| Last Modified: | 08 Aug 2019 11:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9265 |
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