Castrop, Hayo and Schiessl, Ina Maria (2014) Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2). AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 307 (9). F991-F1002. ISSN 1931-857X, 1522-1466
Full text not available from this repository. (Request a copy)Abstract
The Na-K-2Cl cotransporter (NKCC2; BSC1) is located in the apical membrane of the epithelial cells of the thick ascending limb of the loop of Henle (TAL). NKCC2 facilitates similar to 20-25% of the reuptake of the total filtered NaCl load. NKCC2 is therefore one of the transport proteins with the highest overall reabsorptive capacity in the kidney. Consequently, even subtle changes in NKCC2 transport activity considerably alter the renal reabsorptive capacity for NaCl and eventually lead to perturbations of the salt and water homoeostasis. In addition to facilitating the bulk reabsorption of NaCl in the TAL, NKCC2 transport activity in the macula densa cells of the TAL constitutes the initial step of the tubular-vascular communication within the juxtaglomerular apparatus (JGA); this communications allows the TAL to modulate the preglomerular resistance of the afferent arteriole and the renin secretion from the granular cells of the JGA. This review provides an overview of our current knowledge with respect to the general functions of NKCC2, the modulation of its transport activity by different regulatory mechanisms, and new developments in the pathophysiology of NKCC2-dependent renal NaCl transport.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THICK ASCENDING LIMB; K-CL COTRANSPORTER; CALCIUM-SENSING RECEPTOR; TUBULOGLOMERULAR FEEDBACK-REGULATION; DISTAL CONVOLUTED TUBULE; II BARTTERS-SYNDROME; MACULA DENSA; NA+-K+-2CL(-) COTRANSPORTER; BLOOD-PRESSURE; RENIN SECRETION; differential splicing; macula densa; NKCC2; Slc12a1; thick ascending limb |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Petra Gürster |
| Date Deposited: | 11 Aug 2020 14:28 |
| Last Modified: | 11 Aug 2020 14:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9290 |
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