Fenzl, Christoph and Nayak, Pranati and Hirsch, Thomas and Wolfbeis, Otto S. and Alshareef, Husam N. and Baeumner, Antje J. (2017) Laser-Scribed Graphene Electrodes for Aptamer-Based Biosensing. ACS SENSORS, 2 (5). pp. 616-620. ISSN 2379-3694,
Full text not available from this repository. (Request a copy)Abstract
Graphene as a transducer material has produced some of the best performing sensing approaches to date opening the door toward integrated miniaturized all-carbon point-of-care devices. Addressing this opportunity, laser-scribed graphene(LSG) electrodes are demonstrated here as highly sensitive and reliable biosensor transducers in blood serum analysis. These flexible electrodes with large electrochemical surface areas were fabricated using a direct-write laser process on polyimide foils. A universal immobilization approach is established by anchoring 1-pyrenebutyric acid to the graphene and subsequently covalently attaching an aptamer against the coagulation factor thrombin as an exemplary bioreceptor to the carboxyl groups. The resulting biosensor displays extremely low detection limits of 1 pM in buffer and 5 pM in the complex matrix of serum.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LABEL-FREE; ELECTROCHEMICAL SENSORS; HIGH-PERFORMANCE; CARBON; GRAPHITE; FILMS; laser-scribed graphene; biosensor; carbon nanomaterial; aptamer; immobilization; electrochemistry |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 20 Feb 2019 07:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/933 |
Actions (login required)
 |
View Item |
