Schweizer, Daniel and Serno, Tim and Goepferich, Achim (2014) Controlled release of therapeutic antibody formats. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 88 (2). pp. 291-309. ISSN 0939-6411, 1873-3441
Full text not available from this repository. (Request a copy)Abstract
The local administration of antibodies can represent in many cases a significant improvement for antibody-based therapies. The benefits of local delivery include high drug concentrations at the target site, the possibility of lower drug dosing and less systemic drug exposure. Currently, the most relevant delivery sites for therapeutic antibodies are the posterior segments of the eye, mucosal surfaces, the articular joints and the central nervous system (CNS). In addition, the oral and pulmonary route may enable non-invasive systemic antibody delivery. However, local antibody delivery to these sites is characterized by short drug residence times and a low compliance of administration. Controlled release (CR) systems can address these limitations and, thereby, enable and improve local delivery applications by achieving long lasting local drug concentrations, improved efficacy-dosing ratios and reduced treatment-associated side effects. The requirements for CR antibody formulations are more complex compared to conventional CR systems for small molecules, and their development poses an enormous technical challenge. Therefore, the review highlights experiences and challenges gathered in the development of the different CR systems for antibodies to date. Additionally, the unmet technological needs encountered in the field are described. This includes a critical evaluation of the limited capability of various CR systems to preserve antibody stability, delivery site specific considerations, as well as the processability of a CR system with a particular focus on drug loading and injectability. We believe that the success of CR and local delivery approaches could create an enormous added value for patients in the future. (C) 2014 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPINAL-CORD-INJURY; DRUG-DELIVERY SYSTEMS; SINGLE INTRAVITREAL INJECTION; NOGO-66 RECEPTOR ANTIBODY; HYALURONIC-ACID HYDROGEL; MONOCLONAL-ANTIBODY; SUSTAINED-RELEASE; ORAL DELIVERY; PROTEIN AGGREGATION; IN-VIVO; Ocular antibody delivery; Biologic; Formulation; Protein; Antibody therapy; Sustained release; Local delivery; Drug delivery system; Therapeutic antibodies; Polymers |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Aug 2020 06:21 |
| Last Modified: | 07 Aug 2020 06:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9389 |
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