Schiffner, Susanne and Braunger, Barbara M. and de Jel, Miriam M. and Coupland, Sarah E. and Tamm, Ernst R. and Bosserhoff, Anja K. (2014) Tg(Grm1) transgenic mice: A murine model that mimics spontaneous uveal melanoma in humans? EXPERIMENTAL EYE RESEARCH, 127. pp. 59-68. ISSN 0014-4835, 1096-0007
Full text not available from this repository. (Request a copy)Abstract
Although rare, uveal melanoma (UM) is the most common primary intraocular tumor in adults. About half of UM patients develop metastatic disease typically in the liver and die within a short period, due to ineffective systemic therapies. UM has unique and distinct genetic features predictive of metastasis. Animal models are required to improve our understanding of therapeutic options in disseminated UM. Since spontaneous murine UM models are lacking, our aim was to analyze the suitability of the established transgenic melanoma mouse model Tg(Grm1) as a new UM model system. We demonstrated that adult Grm1 transgenic mice develop choroidal thickening and uveal melanocytic neoplasia with expression of the melanocytic markers S100B and MelanA. Further, we showed that GRM1 is expressed in human UM, similar to skin melanoma. This study presents a new mouse model for spontaneous UM and suggests that the glutamate signaling pathway is a possible target for UM therapy. (C) 2014 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METABOTROPIC GLUTAMATE-RECEPTOR-1; OCULAR MELANOMA; MOUSE MODEL; IN-VITRO; CELLS; EXPRESSION; MUTATIONS; TRANSFORMATION; PROGRESSION; MIGRATION; uveal melanoma; melanoma; metabotropic glutamate receptor; Grm1; mouse model |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Aug 2019 09:06 |
| Last Modified: | 13 Aug 2019 09:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9475 |
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