Onken, Julia and Moeckel, Sylvia and Leukel, Petra and Leidgens, Verena and Baumann, Fusun and Bogdahn, Ulrich and Vollmann-Zwerenz, Arabel and Hau, Peter (2014) Versican isoform V1 regulates proliferation and migration in high-grade gliomas. JOURNAL OF NEURO-ONCOLOGY, 120 (1). pp. 73-83. ISSN 0167-594X, 1573-7373
Full text not available from this repository. (Request a copy)Abstract
Versican is a large chondroitin sulphate proteoglycan produced by several tumor cell types, including high-grade gliomas. Increased expression of distinct versican isoforms in the extracellular matrix plays a role in tumor cell growth, adhesion and migration. We have recently shown that transforming growth factor (TGF-beta)2, an important modulator of glioma invasion, interacts with versican isoforms V0/V1 during malignant progression of glioma in vitro. However, the distinct subtype of versican that modulates these effects could not be specified. Here, we show that transient down-regulation of V1 by siRNA leads to a significant reduction of proliferation and migration in glioblastoma cell lines and glioblastoma progenitor cells, whereas tumor cell attachment stays unaffected. We conclude that V1 plays a predominant role in modulating central pathophysiological mechanisms as proliferation and migration in glioblastoma. Considering that TGF-beta is a master regulator of glioma pathophysiology, and that V0/1 is induced by TGF-beta2, therapeutic regulation of V1 may induce meaningful effects on glioma cell migration not only in vitro, but also in vivo.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-BETA; EXTRACELLULAR-MATRIX; CELL INVASION; PROSTATE-CANCER; HUMAN-MELANOMA; PG-M/VERSICAN; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; DIFFERENTIAL REGULATION; SPLICE VARIANTS; Glioblastoma; Glioma; Versican; V1; Migration; Proliferation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Aug 2019 09:38 |
| Last Modified: | 13 Aug 2019 09:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9498 |
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