Graessel, Susanne and Lorenz, Julia (2014) Tissue-Engineering Strategies to Repair Chondral and Osteochondral Tissue in Osteoarthritis: Use of Mesenchymal Stem Cells. CURRENT RHEUMATOLOGY REPORTS, 16 (10): 452. ISSN 1523-3774, 1534-6307
Full text not available from this repository. (Request a copy)Abstract
Focal chondral or osteochondral lesions can be painful and disabling because they have insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for osteoarthritis (OA). Attention has, therefore, been paid to regenerative therapeutic procedures for the early treatment of cartilaginous defects. Current treatments for OA are not regenerative and have little effect on the progressive degeneration of joint tissue. One major reason for this under-representation of regenerative therapy is that approaches to treating OA with cell-based strategies have to take into consideration the larger sizes of the defects, as compared with isolated focal articular-cartilage defects, and the underlying disease process. Here, we review current treatment strategies using mesenchymal stem cells (MSCs) for chondral and osteochondral tissue repair in trauma and OA-affected joints. We discuss tissue-engineering approaches, in preclinical large-animal models and clinical studies in humans, which use crude bone-marrow aspirates and MSCs from different tissue sources in combination with bioactive agents and materials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARTICULAR-CARTILAGE DEFECTS; PARTIAL-THICKNESS DEFECTS; PLATELET LYSATE TECHNIQUE; MARROW STROMAL CELLS; AUTOLOGOUS CHONDROCYTE; KNEE OSTEOARTHRITIS; TRICALCIUM PHOSPHATE; CLINICAL-APPLICATION; FOLLOW-UP; MODEL; Osteoarthritis; Trauma; Cartilage; Focal defect; Clinical; Preclinical; Animal model; Ovine; Porcine; Equine; Chondral; Osteochondral; Hyaline; Mesenchymal stem cells; Platelet-rich plasma; Bone-marrow concentrate; Tissue engineering; Collagen; Fibrin gel |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Aug 2019 10:24 |
| Last Modified: | 13 Aug 2019 10:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9507 |
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