Lohr, Christian and Grosche, Antje and Reichenbach, Andreas and Hirnet, Daniela (2014) Purinergic neuron-glia interactions in sensory systems. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 466 (10). pp. 1859-1872. ISSN 0031-6768, 1432-2013
Full text not available from this repository. (Request a copy)Abstract
The purine adenosine 5'-triphosphate (ATP) and its breakdown products, ADP and adenosine, act as intercellular messenger molecules throughout the nervous system. While ATP contributes to fast synaptic transmission via activation of ionotropic P2X receptors as well as neuromodulation via metabotropic P2Y receptors, ADP and adenosine only stimulate P2Y and P1 receptors, respectively, thereby adjusting neuronal performance. Often glial cells are recipient as well as source for extracellular ATP. Hence, purinergic neuron-glia signalling contributes bidirectionally to information processing in the nervous system, including sensory organs and brain areas computing sensory information. In this review, we summarize recent data of purinergic neuron-glia communication in two sensory systems, the visual and the olfactory systems. In both retina and olfactory bulb, ATP is released by neurons and evokes Ca2+ transients in glial cells, viz. Muller cells, astrocytes and olfactory ensheathing cells. Glial Ca2+ signalling, in turn, affects homeostasis of the nervous tissue such as volume regulation and control of blood flow. In addition, 'gliotransmitter' release upon Ca2+ signalling-evoked by purinoceptor activation-modulates neuronal activity, thus contributing to the processing of sensory information.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METABOTROPIC GLUTAMATE RECEPTORS; OLFACTORY ENSHEATHING CELLS; ADENOSINE A(2A) RECEPTORS; OSMOTIC VOLUME REGULATION; V PYRAMIDAL NEURONS; GATED ION CHANNELS; MULLER CELLS; ATP RELEASE; EXTRACELLULAR ATP; NERVOUS-SYSTEM; ATP; Adenosine; Purinoceptors; Retina; Olfactory bulb; Muller cells; Ensheathing cells; Astrocytes |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Petra Gürster |
| Date Deposited: | 06 Aug 2020 13:49 |
| Last Modified: | 06 Aug 2020 13:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9511 |
Actions (login required)
 |
View Item |
