Ried, M. and Hofmann, H. -S. (2014) Perioperative Antibiotic Therapy in Thoracic Surgery. ZENTRALBLATT FUR CHIRURGIE, 139. S22-S26. ISSN 0044-409X, 1438-9592
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Introduction: In Germany no official guidelines exist for a specific perioperative antibiotic prophylaxis (PAP) in thoracic surgery. In this review, data regarding the PAP as well as antibiotic therapy of the postoperative pneumonia (POP) in thoracic surgery are described. Methods: Selective literature researches were carried out in Medline with consideration of the official recommendations of the Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) as well as Paul-Ehrlich-Gesellschaft fur Chemotherapie e.V. (PEG). Results: The PAP is defined as a short and single application of an antibiotic agent preoperatively or during a surgical intervention. A PAP with first-generation or second-generation cephalosporins could significantly reduce the rate of surgical site infections after thoracic surgery. However, these few randomised trials could not demonstrate a distinct effect on the rate of POP and postoperative empyema. The incidence of POP is approximately 20-25% after major thoracic surgery. Antibiotic therapy of POP should be performed early and be based on antibiotic sensitivity. Conclusion: Based on the few prospective, randomised studies a single dose of intravenous PAP with a cephalosporin is recommended in thoracic surgery. Therapy of the POP should include general procedures combined with a specific antibiotic therapy according to antibiotic sensitivity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURGICAL SITE INFECTIONS; POSTOPERATIVE RESPIRATORY-INFECTIONS; PRACTICE GUIDELINE SERIES; LUNG-CANCER SURGERY; DOUBLE-BLIND; PULMONARY RESECTIONS; NOSOCOMIAL PNEUMONIA; RANDOMIZED-TRIAL; CARDIAC-SURGERY; WOUND-INFECTION; antibiotic prophylaxis; antibiotic treatment; thoracic surgery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Abteilung für Thoraxchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Aug 2019 12:52 |
| Last Modified: | 19 Aug 2019 12:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9616 |
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