Schraivogel, Daniel and Meister, Gunter (2014) Import routes and nuclear functions of Argonaute and other small RNA-silencing proteins. TRENDS IN BIOCHEMICAL SCIENCES, 39 (9). pp. 420-431. ISSN 0968-0004
Full text not available from this repository. (Request a copy)Abstract
Small RNAs are important regulators of gene expression in many different organisms. Nuclear and cytoplasmic biogenesis enzymes generate functional small RNAs from double-stranded (ds) or single-stranded (ss) RNA precursors, and mature small RNAs are loaded into Argonaute proteins. In the cytoplasm, small RNAs guide Argonaute proteins to complementary RNAs leading to cleavage of these targets, translational silencing, or mRNA decay. In the nucleus Argonaute proteins engage in transcriptional silencing processes such as epigenetic silencing of repetitive elements at the chromatin level. During the past few years many novel functions of small RNA-guided gene silencing proteins in the nucleus have been reported. However, their specific import routes are largely unknown. In this review we summarize the current knowledge on nuclear transport routes that Argonaute and other RNA-silencing proteins take to carry out their various functions in the nucleus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOUBLE-STRANDED-RNA; FISSION YEAST DICER; CAENORHABDITIS-ELEGANS; HUMAN-CELLS; TETRAHYMENA-THERMOPHILA; CHROMOSOME SEGREGATION; ARABIDOPSIS-THALIANA; GENOME REARRANGEMENT; MICRORNA BIOGENESIS; TARGET RECOGNITION; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Petra Gürster |
| Date Deposited: | 04 Aug 2020 10:04 |
| Last Modified: | 04 Aug 2020 10:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9674 |
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