Tabatabai, J. and Wenzel, J. J. and Soboletzki, M. and Flux, C. and Navid, M. Heidary and Schnitzler, P. (2014) First case report of an acute hepatitis E subgenotype 3c infection during pregnancy in Germany. JOURNAL OF CLINICAL VIROLOGY, 61 (1). pp. 170-172. ISSN 1386-6532, 1873-5967
Full text not available from this repository. (Request a copy)Abstract
Hepatitis E is usually a self-limiting disease and an important cause of acute hepatitis in endemic countries in Asia and Africa. However, the mortality rate for pregnant women infected with hepatitis E virus (HEV) in this area is about 25%. In Germany, sporadic cases of acute hepatitis E infections have been described and the number of autochthonous infections is increasing. Here we report an autochthonous HEV subgenotype 3c infection in a 27-year old pregnant woman. This is the first documented case of a hepatitis E infection during pregnancy in Germany. The patient presented in week 26 of gestation with acute hepatitis and elevated transaminases. During follow-up, she tested positive for anti-HEV antibodies. HEV viral load during the acute hepatitis was 2.3 x 10(6) copies/ml serum, however viremia declined and cleared rapidly. Sequence analysis revealed a HEV subgenotype 3c closely related to European isolates. The patient had not travelled outside Germany, had regular contact to animals, but the source of infection remains unclear. The newborn was delivered in week 40 of gestation in good health, HEV was not transmitted and liver enzymes were normal. In conclusion, hepatitis E should be considered in differential diagnosis in patients with acute hepatitis especially during pregnancy, even without travel history to countries with high endemicity. (C) 2014 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | E VIRUS-INFECTION; FAILURE; FRANCE; SPAIN; WOMEN; WOMAN; Hepatitis E virus; Pregnancy; Acute hepatitis; Autochthonous hepatitis E |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Aug 2019 11:34 |
| Last Modified: | 29 Aug 2019 11:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9682 |
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