Straub, Rainer H. (2014) TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective. JOURNAL OF MOLECULAR MEDICINE-JMM, 92 (9). pp. 925-937. ISSN 0946-2716, 1432-1440
Full text not available from this repository. (Request a copy)Abstract
Chronic inflammatory diseases are accompanied by a systemic response of the body, necessary to redirect energy-rich fuels to the activated immune system and to induce volume expansion. The systemic response is switched on by two major pathways: (a) circulating cytokines enter the brain, and (b) signals via sensory nerve fibers are transmitted to the brain. Concerning item b, sensory nerve terminals are equipped with a multitude of receptors that sense temperature, inflammation, osmolality, and pain. Thus, they can be important to inform the brain about peripheral inflammation. Central to these sensory modalities are transient receptor potential channels (TRP channels) on sensory nerve endings. For example, TRP vanilloid 1 (TRPV1) can be activated by heat, inflammatory factors (e.g., protons, bradykinin, anandamide), hyperosmolality, pungent irritants, and others. TRP channels are multimodal switches that transmit peripheral signals to the brain, thereby inducing a systemic response. It is demonstrated how and why these TRP channels (TRPV1, TRP ankyrin type 1 (TRPA1), and TRP melastatin type 8 (TRPM8)) are important to start up a systemic response of energy expenditure, energy allocation, and water retention and how this is linked to a continuously activated immune system in chronic inflammatory diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECEPTOR POTENTIAL VANILLOID-1; ROOT GANGLION NEURONS; SENSORY NEURONS; ION-CHANNEL; CAPSAICIN RECEPTOR; PHARMACOLOGICAL BLOCKADE; INSULIN SENSITIVITY; CATION CHANNEL; SUBSTANCE-P; JOINT PAIN; Systemic response; TRP channels; Inflammation; Energy redirection; Water retention |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 04 Aug 2020 10:07 |
| Last Modified: | 04 Aug 2020 10:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9684 |
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