Rosmalen, Judith G. M. and Kema, Ido P. and Wuest, Stefan and van der Ley, Claude and Visser, Sipke T. and Snieder, Harold and Bakker, Stephan J. L. (2014) 24 h urinary free cortisol in large-scale epidemiological studies: Short-term and long-term stability and sources of variability. PSYCHONEUROENDOCRINOLOGY, 47. pp. 10-16. ISSN 0306-4530,
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Background: Function of the hypothalamus-pituitary-adrenal (HPA) axis has been associated with several somatic and psychiatric health problems. The amount of free cortisol excreted in the urine during 24 h (24-h UFC) has often been used as a proxy for HPA-axis function. Reference values for 24-h UFC and their stability in the short and long term, as well as sources of variability, are largely lacking. Methods: This study was performed in a general population cohort. Participants collected 24-h UFC on two consecutive days (T1), and repeated this collection approximately 2 years later (T2). Cortisol in urine was measured using LC-MS/MS. Height and weight were measured at the research facilities; glomerular filtration rate was estimated using creatinine clearance. Psychological distress (General Health Questionnaire), smoking, alcohol use and exercise were measured by means of questionnaires. Results: 24-h UFC stability on a day-to-day basis was 0.69 (T1, N = 1192) and 0.72 (T2, N = 963) (both p < 0.001). Long-term stability as indicated by correlation between 2-day averages of T1 and T2 was 0.60 (N = 972, p < 0.001). Multivariable linear regression analysis revealed that 24-h UFC was predicted by urine volume (standardized beta 0.282 (T1, N = 1556) and 0.276 (T2, N = 1244); both p < 0.001) and glomerular filtration rate (standardized beta 0.137 (T1) and 0.179 (T2); both p < 0.001), while also sex explained a small part (standardized beta for female sex -0.057 (T1) and -0.080 (T2); both p < 0.05). Conclusion: 24-h UFC is moderately stable both in the short and the long term. The effects of urine volume and glomerular filtration rate on 24-h UFC are much stronger than those of sex. (C) 2014 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; HEALTHY-INDIVIDUALS; EXCRETION; POPULATION; SPECIFICITY; COLLECTION; CREATININE; RESPONSES; SYMPTOMS; STRESS; Urinary cortisol; 24-h UFC; Epidemiology; General population; Stability; Variability; Urine volume; Glomerular filtration rate |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Aug 2019 13:50 |
| Last Modified: | 29 Aug 2019 13:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9715 |
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