Mitchell, Caroline M. and McLemore, Leslie and Westerberg, Katharine and Astronomo, Rena and Smythe, Kimberly and Gardella, Carolyn and Mack, Matthias and Magaret, Amalia and Patton, Dorothy and Agnew, Kathy and McElrath, M. Juliana and Hladik, Florian and Eschenbach, David (2014) Long-term Effect of Depot Medroxyprogesterone Acetate on Vaginal Microbiota, Epithelial Thickness and HIV Target Cells. JOURNAL OF INFECTIOUS DISEASES, 210 (4). pp. 651-655. ISSN 0022-1899, 1537-6613
Full text not available from this repository. (Request a copy)Abstract
Background. Depot medroxyprogesterone acetate (DMPA) has been linked to human immunodeficiency virus type 1 (HIV-1) acquisition. Methods. Vaginal microbiota of women using DMPA for up to 2 years were cultured. Mucosal immune cell populations were measured by immunohistological staining. Results. Over 12 months, the proportion with H2O2-positive lactobacilli decreased (n = 32; 53% vs 27%; P = .03). Median vaginal CD3(+) cells also decreased (n = 15; 355 vs 237 cells/mm(2); P = .03), as did CD3(+)CCR5(+) cells (195 vs 128 cells/mm(2); P = .04), HLA-DR+ cells (130 vs 96 cells/mm(2); P = .27), and HLA-DR+ CCR5(+) cells (18 vs 10 cells/mm(2); P = .33). Conclusions. DMPA contraception does not increase vaginal mucosal CCR5(+) HIV target cells but does decrease CD3(+) T lymphocytes and vaginal H2O2-producing lactobacilli.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MENSTRUAL-CYCLE; CONTRACEPTIVES; ACQUISITION; INFECTION; FLORA; HIV; medroxyprogesterone acetate; vaginal mucosa |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Aug 2019 12:48 |
| Last Modified: | 30 Aug 2019 12:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9741 |
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