Kundu, Tanay and Mitra, Shouvik and Patra, Prasun and Goswami, Arunava and Diaz, David Diaz and Banerjee, Rahul (2014) Mechanical Downsizing of a Gadolinium(III)-based Metal-Organic Framework for Anticancer Drug Delivery. CHEMISTRY-A EUROPEAN JOURNAL, 20 (33). pp. 10514-10518. ISSN 0947-6539, 1521-3765
Full text not available from this repository. (Request a copy)Abstract
A Gd-III-based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9x1.2nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (>90min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12wt%) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESOPOROUS SILICA NANOPARTICLES; POROUS COORDINATION POLYMERS; IN-VIVO; DOXORUBICIN; WATER; ADSORPTION; CYTOTOXICITY; PLATFORM; CLUSTER; CANCER; ball-milling; doxorubicin; drug delivery; metal-organic frameworks; nanocarriers |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Sep 2019 12:08 |
| Last Modified: | 03 Sep 2019 12:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9752 |
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