Schueler, Susanne and Lattrich, Claus and Skrzypczak, Maciej and Fehm, Tanja and Ortmann, Olaf and Treeck, Oliver (2014) Polymorphisms in the promoter region of ESR2 gene and susceptibility to ovarian cancer. GENE, 546 (2). pp. 283-287. ISSN 0378-1119, 1879-0038
Full text not available from this repository. (Request a copy)Abstract
Susceptibility to ovarian cancer might be affected by genetic variations in genes involved in estrogen biosynthesis, metabolism or signal transduction. In this study we tested the hypothesis that single nucleotide polymorphisms (SNPs) in the promoter of human ESR2 gene, coding for estrogen receptor beta, may be associated with increased risk for ovarian cancer. Three SNPs in the promoter region of human ESR2 gene were genotyped by means of allele-specific tetra-primer PCR. A total of 184 ovarian cancer cases and the same numbers of controls were included in the study. With regard to homozygous analysis, the AA genotype of SNP rs3020449 was found to be significantly more frequent in ovarian cancer cases staged as FIGO III + IV than in cases staged as I + II (OR 2.717, p = 0.027). With regard to allele frequency, the G allele of this SNP was less frequent in FIGO I + II cases than in cases with higher FIGO stages (OR 1.739, p = 0.018). With regard to genotype frequency, allele frequency, allele positivity or haplotype frequency of SNPs rs2987983, rs3020449 and rs3020450 we did not observe a significant difference between the cancer and the control group. Our data suggest that SNPs in the promoter region of ESR2 gene do not affect susceptibility to ovarian cancer, but SNP rs3020449 might affect progression of this disease. (C) 2014 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESTROGEN-RECEPTOR-BETA; MESSENGER-RNA EXPRESSION; BREAST-CANCER; GROWTH-FACTOR; ASSOCIATION; RISK; ALPHA; VARIANTS; DISEASE; ABSENCE; Ovarian cancer; Estrogen receptor beta; Single nucleotide polymorphism; Case-control study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Sep 2019 13:13 |
| Last Modified: | 03 Sep 2019 13:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9760 |
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