Ott, Christian and Kerscher, Christoph and Luerding, Ralf and Doenitz, Christian and Hoehne, Julius and Zech, Nina and Seemann, Milena and Schlaier, Juergen and Brawanski, Alexander (2014) The Impact of Sedation on Brain Mapping: A Prospective, Interdisciplinary, Clinical Trial. NEUROSURGERY, 75 (2). pp. 117-123. ISSN 0148-396X, 1524-4040
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: During awake craniotomies, patients may either be awake for the entire duration of the surgical intervention (awake-awake-awake craniotomy, AAA) or initially sedated (asleep-awake-asleep craniotomy, SAS). OBJECTIVE: To examine whether prior sedation in SAS may restrict brain mapping, we conducted neuropsychological tests in patients by means of a standardized anesthetic regimen comparable to an SAS. METHODS: We prospectively examined patients undergoing surgery either under total intravenous anesthesia (TIVA) or under regional anesthesia with slight sedation (RAS). The tests included the DO40 picture-naming test, the digit span, the Regensburg Word Fluency Test, and the finger-tapping test. Each test was conducted 3 times for every patient in the TIVA and RAS groups, once before surgery and twice within about 35 minutes after the end of sedation. Patients undergoing AAA were examined preoperatively and intraoperatively. RESULTS: In the AAA group, no significant difference was found between preoperative and intraoperative test results. In the TIVA and RAS groups, postoperative tests showed worse results than preoperative tests. In most tests, patients improved from the first to the second postoperative test. CONCLUSION: Cognitive and motor performance were significantly influenced by prior sedation in the TIVA and RAS groups, but not in the AAA group. Therefore, prior sedation may be assumed to cause a change in the baselines, which may compromise brain mapping and thus endanger a patient's neurological outcome in the case of an SAS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AWAKE CRANIOTOMY; ANESTHETIC MANAGEMENT; SURGERY; PATIENT; NEUROSURGERY; EXPERIENCE; PRESSURE; PROPOFOL; FENTANYL; Anesthetics; Brain mapping; Neuro-oncology; Neuropsychology; Neurosurgery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Sep 2019 13:26 |
| Last Modified: | 04 Sep 2019 13:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9818 |
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