Koehler, Anne C. and Sag, Can M. and Maier, Lars S. (2014) Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 73. pp. 92-102. ISSN 0022-2828, 1095-8584
Full text not available from this repository. (Request a copy)Abstract
Reactive oxygen species (ROS) are highly reactive oxygen-derived chemical compounds that are by-products of aerobic cellular metabolism as well as crucial second messengers in numerous signaling pathways. In excitationcontraction-coupling (ECC), which links electrical signaling and coordinated cardiac contraction, ROS have a severe impact on several key ion handling proteins such as ion channels and transporters, but also on regulating proteins such as protein kinases (e.g. CaMKII, PICA or PKC), thereby pivotally influencing the delicate balance of this finely tuned system. While essential as second messengers, ROS may be deleterious when excessively produced due to a disturbed balance in Na+ and Ca2+ handling, resulting in Na+ and Ca2+ overload, SR Ca2+ loss and contractile dysfunction. This may, in the end, result in systolic and diastolic dysfunction and arrhythmias. This review aims to provide an overview of the single targets of ROS in ECC and to outline the role of ROS in major cardiac pathologies, such as heart failure and arrhythmogenesis. This article is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System" (c) 2014 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-KINASE-C; CHANNEL RYANODINE RECEPTOR; RETICULUM CA2+ LEAK; LATE SODIUM CURRENT; REPERFUSION-INDUCED ARRHYTHMIAS; MEDIATED LIPID-PEROXIDATION; SARCOPLASMIC-RETICULUM; FREE-RADICALS; TROPONIN-I; CALCIUM-RELEASE; Excitation-contraction coupling; Calcium; Sodium; Free radicals; CaMKII |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Petra Gürster |
| Date Deposited: | 04 Aug 2020 09:04 |
| Last Modified: | 04 Aug 2020 09:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9857 |
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