Hauser, Joachim and Reissmann, Andreas and Sontag, Thomas-A. and Tucha, Oliver and Lange, Klaus W. (2017) Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). JOURNAL OF NEURAL TRANSMISSION, 124 (5). pp. 643-654. ISSN 0300-9564, 1435-1463
Full text not available from this repository. (Request a copy)Abstract
The aim of this study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) on attention in rats as measured using the 5-choice-serial-reaction-time task (5CSRTT) and to investigate whether methylphenidate has effects on DSP4-treated rats. Methylphenidate is a noradrenaline and dopamine reuptake inhibitor and commonly used in the pharmacological treatment of individuals with attention deficit/hyperactivity disorder (ADHD). Wistar rats were trained in the 5CSRTT and treated with one of three doses of DSP4 or saline. Following the DSP4 treatment rats were injected with three doses of methylphenidate or saline and again tested in the 5CSRTT. The treatment with DSP4 caused a significant decline of performance in the number of correct responses and a decrease in response accuracy. A reduction in activity could also be observed. Whether or not the cognitive impairments are due to attention deficits or changes in explorative behaviour or activity remains to be investigated. The treatment with methylphenidate had no beneficial effect on the rats' performance regardless of the DSP4 treatment. In the group without DSP4 treatment, methylphenidate led to a reduction in response accuracy and bidirectional effects in regard to parameters related to attention. These findings support the role of noradrenaline in modulating attention and call for further investigations concerning the effects of methylphenidate on attentional processes in rats.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEFICIT HYPERACTIVITY DISORDER; REACTION-TIME-TASK; DORSAL NORADRENERGIC BUNDLE; CORTICAL COGNITIVE FUNCTION; PREFRONTAL CORTEX; LOCUS-COERULEUS; 6-HYDROXYDOPAMINE LESIONS; SELECTIVE ATTENTION; VIGILANCE TASK; ANIMAL-MODELS; Methylphenidate; Attention; Attention deficit hyperactivity disorder; N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine; DSP4; Rat |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 13 Feb 2019 14:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/986 |
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