Klampfl, Stefanie M. and Brunton, Paula J. and Bayerl, Doris S. and Bosch, Oliver J. (2014) Hypoactivation of CRF Receptors, Predominantly Type 2, in the Medial-Posterior BNST Is Vital for Adequate Maternal Behavior in Lactating Rats. JOURNAL OF NEUROSCIENCE, 34 (29). pp. 9665-9676. ISSN 0270-6474,
Full text not available from this repository. (Request a copy)Abstract
Maternal behavior ensures the proper development of the offspring. In lactating mammals, maternal behavior is impaired by stress, the physiological consequence of central corticotropin-releasing factor receptor (CRF-R) activation. However, which CRF-R subtype in which specific brain area(s) mediates this effect is unknown. Here we confirmed that an intracerebroventricularly injected nonselective CRF-R antagonist enhances, whereas an agonist impairs, maternal care. The agonist also prolonged the stress-induced decrease in nursing, reduced maternal aggression and increased anxiety-related behavior. Focusing on the bed nucleus of the stria terminalis (BNST), CRF-R1 and CRF-R2 mRNA expression did not differ in virgin versus lactating rats. However, CRF-R2 mRNA was more abundant in the posterior than in the medial BNST. Pharmacological manipulations within the medial-posterior BNST showed that both CRF-R1 and CRF-R2 agonists reduced arched back nursing (ABN) rapidly and after a delay, respectively. After stress, both antagonists prevented the stress-induced decrease in nursing, with the CRF-R2 antagonist actually increasing ABN. During the maternal defense test, maternal aggression was abolished by the CRF-R2, but not the CRF-R1, agonist. Anxiety-related behavior was increased by the CRF-R1 agonist and reduced by both antagonists. Both antagonists were also effective in virgin females but not in males, revealing a sexual dimorphism in the regulation of anxiety within the medial-posterior BNST. In conclusion, the detrimental effects of increased CRF-R activation on maternal behavior are mediated via CRF-R2 and, to a lesser extent, via CRF-R1 in the medial-posterior BNST in lactating rats. Moreover, both CRF-R1 and CRF-R2 regulate anxiety in females independently of their reproductive status.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORTICOTROPIN-RELEASING-FACTOR; MESSENGER-RNA EXPRESSION; NEUROENDOCRINE STRESS RESPONSES; PITUITARY-ADRENAL AXIS; STRIA TERMINALIS; BED NUCLEUS; BRAIN OXYTOCIN; UROCORTIN-III; PREOPTIC AREA; ANXIETY BEHAVIOR; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2019 08:05 |
| Last Modified: | 16 Sep 2019 08:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9873 |
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