Haimerl, Michael and Verloh, Niklas and Fellner, Claudia and Zeman, Florian and Teufel, Andreas and Fichtner-Feigl, Stefan and Schreyer, Andreas G. and Stroszczynski, Christian and Wiggermann, Philipp (2014) MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score. SCIENTIFIC REPORTS, 4: 5621. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUANTITATIVE-EVALUATION; DISEASE MELD; HEPATOCELLULAR-CARCINOMA; HISTOPATHOLOGIC FINDINGS; HEPATOBILIARY PHASE; IMAGING EVALUATION; CIRRHOTIC LIVERS; CONTRAST AGENTS; RELAXATION-TIME; IN-VIVO; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2019 12:31 |
| Last Modified: | 12 Sep 2019 12:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9894 |
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