Laschkolnig, Anja and Kollerits, Barbara and Lamina, Claudia and Meisinger, Christa and Rantner, Barbara and Stadler, Marietta and Peters, Annette and Koenig, Wolfgang and Stoeckl, Andrea and Daehnhardt, Doreen and Boeger, Carsten A. and Kraemer, Bernhard K. and Fraedrich, Gustav and Strauch, Konstantin and Kronenberg, Florian (2014) Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts. CARDIOVASCULAR RESEARCH, 103 (1). pp. 28-36. ISSN 0008-6363, 1755-3245
Full text not available from this repository. (Request a copy)Abstract
The relevance of lipoprotein(a) [Lp(a)] concentrations and low-molecular-weight (LMW) apo(a) phenotypes in peripheral arterial disease (PAD) has only been investigated by few studies. Therefore, we analysed this association in three independent cohorts and performed a Mendelian Randomization approach using instrumental variable regression. Lp(a) concentrations, apo(a) phenotypes, and one SNP in the LPA gene (rs10455872) were measured in the CAVASIC study, including 241 male patients with intermittent claudication and 246 age- and diabetes-matched controls as well as in the two population-based studies KORA F3 (n = 3184) and KORA F4 (n = 3080). In KORA F3/F4, 109/80 persons suffered from intermittent claudication, 200/144 from PAD, and 128/103 showed an ankle-brachial index (ABI) < 0.9. In CAVASIC, adjusted logistic regression analyses revealed significant associations between an increase of log-Lp(a) per one standard deviation (SD) (OR = 1.28, P = 0.02) as well as LMW apo(a) phenotypes and symptomatic PAD (OR = 1.65, P = 0.03). Linear regression models with continuous ABI showed a significant association in the combined analyses of KORA F3/F4: an increase in log-Lp(a) per one SD (beta = -0.006, P = 0.005) and the presence of LMW apo(a) phenotypes (beta = -0.011, P = 0.02) or the minor allele of rs10455872 (beta = -0.016, P = 0.03) were associated with a decrease in ABI in the fully adjusted linear and instrumental variable regression models. Analyses in three independent populations showed significant associations of Lp(a) concentrations, LMW apo(a) phenotypes, and rs10455872 with PAD. This points to a causal relationship between Lp(a) and PAD since the genetically determined apo(a) phenotypes and SNP alleles are indeed associated with PAD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-HEART-DISEASE; ANKLE-BRACHIAL INDEX; NUTRITION EXAMINATION SURVEY; INTERMITTENT CLAUDICATION; RISK-FACTORS; VASCULAR-DISEASE; FOLLOW-UP; SYSTEMIC ATHEROSCLEROSIS; NATIONAL-HEALTH; ASSOCIATION; Lp(a) concentrations; Apolipoprotein(a) phenotypes; Peripheral arterial disease; Ankle-brachial index; Mendelian randomization; Causality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Oct 2019 09:28 |
| Last Modified: | 17 Oct 2019 09:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9930 |
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