Hernowo, Aditya T. and Prins, Doety and Baseler, Heidi A. and Plank, Tina and Gouws, Andre D. and Hooymans, Johanna M. M. and Morland, Antony B. and Greenlee, Mark W. and Cornelissen, Frans W. (2014) Morphometric analyses of the visual pathways in macular degeneration. CORTEX, 56. pp. 99-110. ISSN 0010-9452, 1973-8102
Full text not available from this repository. (Request a copy)Abstract
Introduction: Macular degeneration (MD) causes central visual field loss. When field defects occur in both eyes and overlap, parts of the visual pathways are no longer stimulated. Previous reports have shown that this affects the grey matter of the primary visual cortex, but possible effects on the preceding visual pathway structures have not been fully established. Methods: In this multicentre study, we used high-resolution anatomical magnetic resonance imaging and voxel-based morphometry to investigate the visual pathway structures up to the primary visual cortex of patients with age-related macular degeneration (AMD) and juvenile macular degeneration (JMD). Results: Compared to age-matched healthy controls, in patients with JMD we found volumetric reductions in the optic nerves, the chiasm, the lateral geniculate bodies, the optic radiations and the visual cortex. In patients with AMD we found volumetric reductions in the lateral geniculate bodies, the optic radiations and the visual cortex. An unexpected finding was that AMD, but not JMD, was associated with a reduction in frontal white matter volume. Conclusion: MD is associated with degeneration of structures along the visual pathways. A reduction in frontal white matter volume only present in the AMD patients may constitute a neural correlate of previously reported association between AMD and mild cognitive impairment. (C) 2013 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AGE-RELATED MACULOPATHY; GEOGRAPHIC ATROPHY; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; CORTICAL REORGANIZATION; FIBER TRACTS; RISK-FACTORS; HUMAN BRAIN; PREVALENCE; CORTEX; Macular degeneration; Visual pathway; Visual field; Voxel-based morphometry |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Oct 2019 11:01 |
| Last Modified: | 17 Oct 2019 11:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9950 |
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