Streit, Fabian and Haddad, Leila and Paul, Torsten and Frank, Josef and Schaefer, Axel and Nikitopoulos, Joerg and Akdeniz, Ceren and Lederbogen, Florian and Treutlein, Jens and Witt, Stephanie and Meyer-Lindenberg, Andreas and Rietschel, Marcella and Kirsch, Peter and Wuest, Stefan (2014) A functional variant in the neuropeptide S receptor 1 gene moderates the influence of urban upbringing on stress processing in the amygdala. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 17 (4). pp. 352-361. ISSN 1025-3890, 1607-8888
Full text not available from this repository. (Request a copy)Abstract
We have previously shown that urban upbringing and city living were associated with stress-induced activity in the amygdala and the perigenual anterior cingulate cortex (pACC). This finding might link the epidemiological risk factor "urbanicity" to neurobiological mechanisms of psychiatric disorders. However, given the heritability of stress-related phenotypes, it appears likely that genetic factors can modulate the effect of urbanicity on social stress processing. In the present exploratory study, we investigated if a functional sequence variation in the neuropeptide S receptor gene (NPSR1 rs324981) is associated with brain activation patterns under acute psychosocial stress and if it modulates the link between urbanicity and central stress processing. In animals, neuropeptide S has strong anxiolytic effects and it induces hypothalamus-pituitary-adrenal (HPA) axis activation. In humans, rs324981 was found to be associated with anxiety and stress-related phenotypes. Forty-two subjects were exposed to a psychosocial stress task for scanner environments (ScanSTRESS). While no main effect of rs324981 on amygdala and pACC activity was detected, we found a distinct interaction between rs324981 and urban upbringing modulating right amygdala responses. Moreover, right amygdala responses were significantly higher in subjects who also showed a salivary cortisol response to the stress exposure. The present finding of a gene x environment interaction further supports the view that the brain NPS system is involved in central stress regulation. This study provides first evidence for the assumption that a NPSR1 variant modulates brain activation under stress, interacting with the environmental risk factor urban upbringing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; PSYCHOSOCIAL STRESS; SOCIAL STRESS; ENVIRONMENT INTERACTION; CORTISOL RESPONSES; PANIC DISORDER; SCHIZOPHRENIA; DEPRESSION; BRAIN; METAANALYSIS; Amygdala; fMRI; gene x environment interaction; HPA axis; neuropeptide receptor gene; psychosocial stress; urban upbringing |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Oct 2019 11:18 |
| Last Modified: | 17 Oct 2019 11:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9961 |
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